Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Indirubin-3'-monoxime

Inhibitor of CDK and GSK
 
BML-CC207-0001 1 mg 81.00 USD
 
BML-CC207-0005 5 mg 332.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-270-271

A potent inhibitor of glycogen synthase kinase-3β (IC50=22 nM). Also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM). It reversibly arrests asynchronous HBL-100 cells at G2. Induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM).

Product Specification

Formula:C16H11N3O2
 
MW:277.3
 
CAS:160807-49-8
 
Purity:≥98%
 
Appearance:Dark red solid.
 
Solubility:Soluble in DMSO (6mg/ml) and ethanol (4mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
bml-cc207
Please mouse over
bml-cc207

Product Literature References

Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3´-monoxime: E.H. Heiss, et al.; Vascul. Pharmacol. 83, 47 (2016), Application(s): Cell culture, Abstract;
Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest: E. Damiens, et al.; Oncogene 20, 3786 (2001), Abstract;
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001), Abstract;
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells: D. Marko, et al.; Br. J. Cancer 84, 283 (2001), Abstract;
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases: R. Hoessel, et al.; Nat. Cell. Biol. 1, 60 (1999), Abstract;

Related Literature

Brochures
Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

Brochures
Stem Cells
Stem Cells
Download as PDF

Catalogs
Diabetes Catalog
Diabetes Catalog
Download as PDF

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

Product Flyers
Cell Cycle - Mitosis, CDKS & Cell Cycle Signaling
Cell Cycle - Mitosis, CDKS & Cell Cycle Signaling
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,