W-7

Calmodulin inhibitor



BML-CA320-0050	50 mg	85.00 USD

Replaces Prod. #: ALX-270-153

Binds to calmodulin, inhibiting Ca²⁺-calmodulin-regulated enzyme activity. It inhibits the Ca²⁺/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC₅₀=25 µM). Cell permeable.

Product Specification

Alternative Name:	N-(6-Aminohexyl)-5-chloro-1-naphtalene-sulfonamide . HCl

Formula:	C₁₆H₂₁ClN₂O₂S . HCl

MW:	377.4

Purity:	99% (TLC)

Appearance:	White solid.

CAS:	61714-27-0

Solubility:	Soluble in water (warm), methanol, 100% ethanol (10mg/ml) (warm), DMSO (25mg/ml), dimethyl formamide or ethylene glycol.

Long Term Storage:	Ambient

Use/Stability:	Stable for at least 2 year after receipt when stored at room temperature. Stock solutions are stable for for up to 3 months at -20°C.

Handling:	Protect from light.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.: H. Itoh & H. Hidaka; J. Biochem 96, 1721 (1984), Abstract;

Calmodulin antagonists' binding sites on calmodulin.: T. Tanaka, et al.; Pharmacology 26, 249 (1983), Abstract;

Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives.: H. Hidaka, et al.; Mol. Pharmacol. 20, 571 (1981), Abstract;

N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.: H. Hidaka, et al.; PNAS 78, 4354 (1981), Abstract; Full Text