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Calcitonin gene related peptide polyclonal antibody

 
BML-CA1137-0025 25 µl 108.00 USD
 
BML-CA1137-0100 100 µl 345.00 USD
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Product Specification

Alternative Name:CGRP
 
Host:Sheep
 
Immunogen:Synthetic peptide corresponding to a portion of rat α-calcitonin gene-related peptide (CGRP).
 
UniProt ID:P01256
 
Species reactivity:Human, Mouse, Rat
Rabbit
 
Crossreactivity:Likely to react with other mammalien species (based on homology, not tested).
 
Applications:IHC
 
Purity Detail:Ammonium sulphate precipitation.
 
Formulation:Liquid. In PBS containing 0.1% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Calcitonin gene-related peptide (CGRP) is a 37-amino acid disulphide-bridged sensory neuropeptide present in the central and peripheral nervous systems of many animal species. Two forms of CGRP (α and β) have been identified from both rat and human, and the sequence of chicken CGRP has also been reported, showing striking structural similarity to the mammalian forms. CGRP is abundant in perivascular sensory neurons and is known to be a potent vasodilator. Recent work supports the rôle of CGRP in mediating skin vasodilatation and differential mesenteric artery vasorelaxation, as well as serving as an endogenous myocardial protective substance with a possible involvement in the inhibition of human platelet aggregation. CGRP is frequently co-localised with Substance P and immunoelectron microscopic observations have shown that the peptides are co-stored in single secretory granules both in sensory neurons and in thyroid C-cells. There are many hundreds of reports in the scientific literature describing the localisation and co-existence of CGRP with other transmitter molecules in a vast array of mammalian and non-mammalian species.
 
Technical Info/Product Notes:Application Data details.
Test tissues: Rat thoracolumbar spinal cord.
Fixatives: Recommended fixative is 4% formaldehyde (prepared from para-polymer) in 0.1M sodium phosphate buffer (pH 7.2-7.4). Perfusion fixation is recommended if possible.
 
BML-CA1137 IHC
Immunohistochemistry analysis: Vibratome (70μm) sections of rat spinal cord immunostained with sheep polyclonal antiserum to CGRP (Prod. No. BML-CA1137) at a dilution of 1:1000. Negative images of fluorescence detection procedure (Alexa488 conjugated secondary antibody). Micrograph courtesy of Professor Andrew Todd (University of Glasgow).
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BML-CA1137 IHC

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