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Screen-Well® ICCB Known Bioactives library

 
BML-2840-0100 1 Library 100 µl/well INQUIRE
 
The ICCB Known Bioactives Library is an important product for use in chemical genetics and drug discovery. The library is a collection of 480 diverse biologically active compounds with defined biological activity and was developed in collaboration with the Harvard Institute of Chemistry and Cell Biology. It includes the following classes of compounds: GPCR ligands, Second messenger modulators, Nuclear receptor ligands, Actin & tubulin modulators, Kinase inhibitors, Protease inhibitors, Ion channel blockers, Gene regulation agents, Lipid biosynthesis inhibitors, many other classes. Each compound is supplied dissolved in DMSO at 100µL and is ready for assaying. The library can be used for assay development and validation, mechanism profiling, lead screening or as a reference library.

Product Specification

Quantity:100µl per well
 
Concentration:DMSO solutions (concentration vary by compound and are provided in the documentation)
 
Long Term Storage:-80°C
 
Kit/Set Contains:480 compounds. Includes compounds that affect most cellular processes and drug targer classes, including: GPCR ligands, Second messenger modulators, Nuclear receptor ligands, Actin and tubulin modulators, Kinase inhibitors, Protease inhibitors, Ion channel blockers, Gene regulation agents, Lipid biosynthesis inhibitors, Phosphodiesterase inhibitors, and many other classes.
 
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Product Literature References

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions: C. Wenzel, et al.; Exp. Cell Res. (2014), Abstract;
Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes: S.Y. Shaw et al.; Proc. Natl. Acad. Sci. USA 108, 492 (2011), Application, Abstract;
High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model: J. Schulte et al.; PLoS One 6, e23841 (2011), Application, Abstract;
Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila: X. Charpentier et al.; PLoS Pathog. 5, e1000501 (2009), Application, Abstract;
Identification of AML1-ETO modulators by chemical genomics: S.M. Corsello; Blood 113, 6193 (2009), Application, Abstract;

General Literature References

Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein: H. Pan et al.; J. Biol. Chem. 283, 33808 (2008), Abstract;
Scaffold composition and biological relevance of screening libraries: A. Shelat et al.; Nat. Chem. Biol. 3, 442 (2007), Abstract;
Small molecule regulators of autophagy identified by an image-based high-throughput screen: L. Zhang et al.; Proc. Natl. Acad. Sci. USA 104, 19023 (2007), Abstract;

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