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SCREEN-WELL® Autophagy library

Structurally and mechanistically different compounds for studying the roles of pro- and anti-autophagic molecules in cells and in vitro applications.
 
BML-2837-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2837-0100 1 Library 100 µl/well Inquire for pricing
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The SCREEN-WELL® Autophagy library contains 94 compounds with defined autophagy-inducing or -inhibitory activity. Compounds are dissolved in DMSO at 10mM or 1mM and aliquoted into deep-well plates at 100 or 500µl per well. A variety of structurally and mechanistically different compound classes are included. A useful tool for studying the roles of pro- and anti-autophagic molecules in cells as well as for use in in vitro applications.

Product Specification

Applications:HTS
 
Kit/Set Contains:94 compounds with defined autophagy-inducing or -inhibitory activity.  A variety of structurally and mechanistically different compound classes are included.
 
Quantity:100 µl/well or 500 µl/well
 
Concentration:DMSO solutions (10mM) except for Bafilomycin A which is provided at 1mM in DMSO.
 
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Technical Info/Product Notes:

Application Note: Cell-Based Screening of Focused Bioactive Compound Libraries: Assessing Small Molecule Modulators of the Canonical Wnt Signaling and Autophagy-Lysosome Pathways.
 

Product Literature References

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia: C.J. Holler, et al.; Mol. Neurodegener. 11, 46 (2016), Abstract; Full Text

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