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ADMA (human) ELISA kit

 
ALX-850-323-KI01 96 wells 1,272.00 USD
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Replaces Prod. #: ALX-850-323/1

Product Specification

Sensitivity:0.05μmol/l (expected value: 0.45µmol/l ± 0.19µmol/l)
 
Assay Time:15 to 20 hours + 1 hour
 
Applications:ELISA
 
Application Notes:For the quantitative determination of asymmetrical dimethylarginine (ADMA) in human serum, citrate- and EDTA-plasma. Does not cross-react with SDMA, NMMA or L-arginine.
 
Species reactivity:Human
 
Quantity:96 wells (~80 tests).
 
Handling:Store standard and controls at -20°C. Store rest of the kit at +4°C.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:+4°C
 
Scientific Background:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis. NO is one of the major endothelium-derived vasoactive mediators and is involved in the modulation of blood flow and blood pressure. Even small changes of ADMA concentration alter vascular NO production, vascular tone, and systemic vascular resistence. Elevated ADMA concentrations are found in patients with diabetes mellitus, hypercholeste-rolemia, hypertension, pulmonary hypertension, peripheral arterial disease, chronic renal failure, preeclampsia or erectile dysfunction. ADMA is therefore a cardiovascular risk factor.
 

Product Literature References

Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise: D.S. Willoughby, et al.; Int. J. Sport Nutr. Exerc. Metab. 21, 291 (2011), Abstract; Full Text
Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculature: M. Potenza, et al.; Am. J. Physiol. Endocrinol. Metab. 297, E685 (2009), Abstract; Full Text

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