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CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate)

 
ALX-805-046B-C050 50 µg Biotin 194.00 USD
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Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

Product Specification

Alternative Name:TNFRSF 5
 
Clone:FGK45
 
Host:Rat
 
Isotype:IgG2a
 
Immunogen:Recombinant mouse CD40 fusion protein.
 
UniProt ID:P27512
 
Species reactivity:Mouse
 
Applications:Flow Cytometry
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In sterile PBS.
 
Handling:Do not freeze. Protect from light.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:+4°C
 
805-046
Figure: Two-color analysis of the expression of CD40 on mouse spleen cells. Splenocytes were simultaneously stained with APC-conjugated anti-B220 MAb and biotinylated FGK45 MAb to CD40 (Prod. No. ALX-805-046) followed by a streptavidin-R-PE conjugate. Specificity of FGK45 towards CD40 was confirmed on splenocytes from -/- CD40 mice and a biotin-conjugated isotype control.
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Product Literature References

Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus: C. Bartholdy, et al.; J. Immunol. 178, 1662 (2007), Abstract;
IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling: P.W. Hellings, et al.; J. Immunol. 177, 5138 (2006), Abstract;
In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN: J.A. Greene, et al.; J. Immunol. 176, 5995 (2006), Abstract;
IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature 434, 772 (2005), Abstract;
CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes: C.M. McGregor, et al.; PNAS 101, 9345 (2004), Abstract; Full Text
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system: A. Erlebacher, et al.; J. Clin. Invest. 114, 39 (2004), Abstract; Full Text
Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells: J.G. Turner, et al.; J. Immunol. 166, 89 (2001), Abstract;
Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process: C. Mauri, et al.; Nat. Med. 6, 673 (2000), Abstract;
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity: A.G. Rolink, et al.; Eur. J. Immunol. 28, 3738 (1998), Abstract;
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching: A. Rolink, et al.; Immunity 5, 319 (1996), Abstract;

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