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Noxa monoclonal antibody (114C307.1)

ALX-804-408-C100 100 µg 344.00 USD
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Product Specification

Immunogen:Recombinant human Noxa.
UniProt ID:Q13794
Species reactivity:Human, Mouse
Applications:ICC, IHC (PS), WB
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 5µg/ml)
Western Blot (1-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~11kDa by Western blot.
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
Use/Stability:Stable for 6 months when stored at +4°C.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Figure: Western blot detection of Noxa in RL-7 cell (a follicular lymphoma) lysate. A protein band of approximate molecular weight of ~11kDa was detected using ALX-804-408 at 2µg/ml dilution.
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Product Literature References

Increased expression of importin-β, exportin-5 and nuclear transportable proteins in Alzheimer's disease aids anatomic pathologists in its diagnosis: G. Nuovo, et al.; Ann. Diag. Pathol. 32, 10 (2018), Application(s): Immunohistochemistry on human brain FFPE tissue, Abstract;
Assessment of Drug Sensitivity in Hematopoietic Stem and Progenitor Cells From Acute Myelogenous Leukemia and Myelodysplastic Syndrome Ex Vivo: K. L. Knorr, et al.; Stem Cells Transl. Med. 6, 840 (2017), Abstract; Full Text
Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs: M.T. Meister, et al.; Cancer Lett. 381, 287 (2016), Application(s): Western blot analysis, Abstract;
Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis: P. Gomez-Bougie, et al.; Cancer Lett. 383, 204 (2016), Application(s): Immunoblotting, human myeloma cell lines, Abstract;
MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies: G. S. Choudhary, et al.; Cell Death Dis. 6, e1593 (2015), Application(s): Western Blotting, Abstract; Full Text
MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors: K.L.B. Knorr, et al.; Cell Death Differ. 22, 2133 (2015), Application(s): Western Blot, Abstract;
Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis: S. Ying, et al.; Infect. Immun. 73, 1399 (2005), Abstract; Full Text
BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis: A.G. Yakovlev, et al.; J. Biol. Chem. 279, 28367 (2004), Abstract; Full Text
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation: S. Erster, et al.; Mol. Cell. Biol. 24, 6728 (2004), Abstract; Full Text
p53 has a direct apoptogenic role at the mitochondria: M. Mihara, et al.; Mol. Cell 11, 577 (2003), Abstract;
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage: B.E. Deverman, et al.; Cell 111, 51 (2002), Abstract;

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