Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

RIP3 (human) monoclonal antibody (Rippy-3)

 
ALX-804-155-C100 100 µg 367.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:Receptor-interacting serine/threonine protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3
 
Clone:Rippy-3
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human RIP3 (receptor-interacting protein 3).
 
UniProt ID:Q9Y572
 
Species reactivity:Human
 
Applications:WB
 
Positive Control:For Positive Control (Western blot) see Prod. No. ALX-840-608.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNF-R1 and Fas, two prototype members in the death receptor family. A member in the RIP kinase family was identified and designated RIP3. RIP3 contains an N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNF-R1, mediates TNF-R1 induced apoptosis, and attenuates RIP and TNF-R1 induced NF-κB activation. Overexpression of RIP3 induces apoptosis and NF-κB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues. Meanwhile RIP4 has been identified and initially characterized. These data suggest that RIP4 is involved in NF-κB and JNK signalling and that caspase-dependent processing of RIP4 may negatively regulate NF-κB-dependent pro-survival or pro-inflammatory signals.
 

General Literature References

RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis: E. Meylan, et al.; EMBO Rep. 3, 1201 (2002), Abstract; Full Text
Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB: P.W. Yu, et al.; Curr. Biol. 9, 539 (1999), Abstract;
Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB: N.J. Pazdernik, et al.; Mol. Cell. Biol. 19, 6500 (1999), Abstract; Full Text
RIP3, a novel apoptosis-inducing kinase: X. Sun, et al.; J. Biol. Chem. 274, 16871 (1999), Abstract; Full Text

Related Products

RIP2 (human) monoclonal antibody (Nick-1) 

WB | Print as PDF
 
ALX-804-139-C100 100 µg 356.00 USD
Do you need bulk/larger quantities?
 

Positive control (cell lysate), for antibodies to RIP3 (human) 

Whole cell lysate of HEK 293T cells transfected with an expression plasmid for human RIP3 (receptor-interacting Protein 3) (aa 1-519) fused at the C-terminus to a FLAG®-tag. | Print as PDF
 
ALX-840-608-R100 100 µl 48.00 USD
Do you need bulk/larger quantities?
 

Product Toolbox

PRODUCT RESOURCES

Print as PDF
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
RIP
By biological activity:
RIP Monoclonal antibody
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
Keep in touch

©2017 Enzo Life Sciences, Inc.,