(+)-Bicuculline

GABA_A receptor antagonist



ALX-550-515-M050	50 mg	42.00 USD

ALX-550-515-M250	250 mg	165.00 USD

GABA_A receptor antagonist.

Product Specification

Alternative Name:	D-Bicuculline

Formula:	C₂₀H₁₇NO₆

MW:	367.4

Purity:	≥98% (HPLC)

Appearance:	Off-white to yellow powder.

CAS:	485-49-4

MI:	14: 1203

RTECS:	LV0909840

Solubility:	Soluble in benzene, chloroform or ethyl acetate.

Long Term Storage:	-20°C

Hazard:	TOXIC.

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Product Literature References

Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production: Sarah E. Hoey, et al.; J. Neurosci. 29, 4442 (2009), Abstract;

Convulsant bicuculline modifies CNS muscarinic receptor affinity: P.G. Schneider and G. Rodriguez de Lores Arnaiz; BMC Neurosci. 7, 32 (2006), Abstract; Full Text

Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats: S. Koda, et al.; Biomed. Res. 26, 241 (2005), Abstract; Full Text