GABAA receptor antagonist.
Product Details
| Alternative Name: | D-Bicuculline |
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| Formula: | C20H17NO6 |
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| MW: | 367.4 |
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| CAS: | 485-49-4 |
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| MI: | 14: 1203 |
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| RTECS: | LV0909840 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white to yellow powder. |
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| Solubility: | Soluble in benzene, chloroform or ethyl acetate. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Amyloid β oligomers disrupt piriform cortical output via a serotonergic pathway: X. Wang, et al.; Neurobiol- Aging
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Abstract;
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition: G. Figlia, et al.; Nat. Cell Biol.
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Abstract;
Nuclear calcium signaling induces expression of the synaptic organizers lrrtm1 and lrrtm2: S.N. Hayer, et al.; J. Biol. Chem.
290, 5523 (2015),
Application(s): Cell Culture,
Abstract;
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Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production: Sarah E. Hoey, et al.; J. Neurosci.
29, 4442 (2009),
Abstract;
Convulsant bicuculline modifies CNS muscarinic receptor affinity: P.G. Schneider and G. Rodriguez de Lores Arnaiz; BMC Neurosci.
7, 32 (2006),
Abstract;
Full Text
Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats: S. Koda, et al.; Biomed. Res.
26, 241 (2005),
Abstract;
Full Text
