Potent and selective antagonist for mGluR5 receptor. Systemically active in vivo.
Product Details
| Alternative Name: | 6-Methyl-2-(phenylethynyl)-pyridine . HCl |
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| Formula: | C14H11N . HCl |
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| MW: | 193.3 . 36.5 |
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| CAS: | 96206-92-7 |
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| Purity: | ≥99% |
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| Identity: | Determined by NMR. |
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| Appearance: | Off-white powder. |
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| Solubility: | Soluble in water, DMSO or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats: M. Pietraszek, et al.; Eur. J. Pharmacol.
514, 25 (2005),
Abstract;
Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats: possible relevance to the effects of mGlu5R blockade in Parkinson’s disease: M.R. Domenici, et al.; J. Neurosci. Res.
80, 646 (2005),
Abstract;
In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling: J.M. Wieronska, et al.; Neuropsychopharmacology
29, 514 (2004),
Abstract;
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Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo: C.A. Heidbreder, et al.; Synapse
50, 269 (2003),
Abstract;
Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence: L.S. Thomas, et al.; Neuropharmacology
41, 523 (2001),
Abstract;
Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist: E. Tatarczynska, et al.; Br. J. Pharmacol.
132, 1423 (2001),
Abstract;
Full Text
Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893): A.G. Chapman, et al.; Neuropharmacology
39, 1567 (2000),
Abstract;
Methylphenylethynylpyridine (MPEP) Novartis: F. Micheli; Curr. Opin. Investig. Drugs
1, 355 (2000),
Abstract;
Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective: V. Bruno, et al.; Neuropharmacology
39, 2223 (2000),
Abstract;
2-Methyl-6-(Phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active MGlu5 receptor antagonist: F. Gasparini, et al.; Neuropharmacology
38, 1493 (1999),
Abstract;
Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus: T.E. Salt, et al.; Br. J. Pharmacol.
127, 1057 (1999),
Abstract;
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology
38, 1431 (1999),
Abstract;
