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Valproic acid . sodium salt

Anticonvulsant and anti-depressant
 
ALX-550-304-G005 5 g 35.00 USD
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Anticonvulsant, anti-depressant and potent teratogen. Inhibits histone deacetylase 1 (HDAC1) (IC50=0.4mM). Inhibitor of human cytochrome P450 2C9 isoform (Ki=600µM). Inducer of apoptosis in human leukemia cells. In nude mice experiments, inhibits significantly human uterine tumor growth without toxic side effects. Modulates the firing of neurons.

Product Specification

Alternative Name:2-Propylpentanoic acid . Na, Sodium 2-propylpentanoate
 
Formula:C8H15O2 . Na
 
MW:143.2 . 23.0
 
CAS:1069-66-5
 
MI:14: 9913
 
Purity:≥98% (GC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water (50mg/ml) or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Hygroscopic.
 
550-304
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550-304

Product Literature References

Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells: K. Kallsen, et al.; PLoS One 7, e50000 (2012), Abstract; Full Text
Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells: K. Huber, et al.; J. Biol. Chem. 286, 22211 (2011), Abstract; Full Text
Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1: S. Shetty, et al.; Mol. Cell. Biol. 25, 5404 (2005), Abstract; Full Text
Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells: N. Takai, et al.; Clin. Cancer Res. 10, 1141 (2004), Abstract;
Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways: R. Kawagoe, et al.; Leuk. Res. 26, 495 (2002), Abstract;
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen: C.J. Phiel, et al.; J. Biol. Chem. 276, 36734 (2001), Abstract; Full Text
In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9): X. Wen, et al.; Br. J. Clin. Pharmacol. 52, 547 (2001), Abstract;
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells: M. Gottlicher, et al.; EMBO J. 20, 6969 (2001), Abstract;
Mechanisms of action of valproate: a commentatory: C.U. Johannessen; Neurochem. Int. 37, 103 (2000), (Review), Abstract;
Actions of sodium valproate on the central nervous system: G. Tunnicliff; J. Physiol. Pharmacol. 50, 347 (1999), (Review), Abstract;
Maternal valproic acid and congenital neural tube defects: E. Robert & P. Guibaud; Lancet 2, 937 (1982), Abstract;
The mechanism of action of sodium valproate: R.W. Kerwin & P.V. Taberner; Gen. Pharmacol. 12, 71 (1981), (Review), Abstract;
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy: R.M. Pinder, et al.; Drugs 13, 81 (1977), (Review), Abstract;

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