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DMNQ

Inducer of intracellular ROS generation
 
ALX-420-027-M005 5 mg 85.00 USD
 
ALX-420-027-M010 10 mg 128.00 USD
 
ALX-420-027-M025 25 mg 279.00 USD
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Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. DMNQ does not react with free thiol groups, is non-alkylating and adduct-forming in contrast to other quinones. Thus, DMNQ is a valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis.

Product Specification

Alternative Name:2,3-Dimethoxy-1,4-naphthoquinone
 
Formula:C12H10O4
 
MW:218.2
 
CAS:6956-96-3
 
Purity:≥99% (TLC)
 
Identity:Determined by NMR.
 
Appearance:Yellow crystalline solid.
 
Solubility:Soluble in acetone, DMSO or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
ALX-420-027
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ALX-420-027

Product Literature References

The Bioenergetic Health Index is a Sensitive Measure of Oxidative Stress in Human Monocytes: B.K. Chacko, et al. ; Redox Biol. 8, 43 (2015), Application(s): Inhibited mitochondrial function in human monocytes, Abstract;
Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype: M.R. King, et al.; J. Immunol. 176, 2765 (2006), Abstract; Full Text
Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells: K.F. Beck, et al.; FEBS Lett. 435, 35 (1998), Abstract;
The relative importance of oxidative stress versus arylation in the mechanism of quinone-induced cytotoxicity to platelets: S.A. Seung, et al.; Chem. Biol. Interact. 113, 133 (1998), Abstract;
DNA single-strand breakage in mammalian cells induced by redox cycling quinones in the absence of oxidative stress: W.A. Morgan; J. Biochem. Toxicol. 10, 227 (1995), Abstract;
Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells: J.M. Dypbukt, et al.; J. Biol. Chem. 269, 30553 (1994), Abstract; Full Text

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