Antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5’-GA-3’ and, to a lesser extent, at 5’-GG-3’ sequences. Forms an intrastrand cross-link at the 5’-GA-3’ sequence, in addition to monoalkylation. Selectively induces normal human fibroblast senescence through Erk and p38 pathways.
Product Details
| Alternative Name: | 1,4-Butanediol dimethanesulfonate |
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| Formula: | C6H14O6S2 |
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| MW: | 246.3 |
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| Source: | Synthetic. |
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| CAS: | 55-98-1 |
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| MI: | 14: 1505 |
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| RTECS: | EK1750000 |
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| Purity: | ≥98% (Assay) |
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| Identity: | Determined by NRM and LCMS. |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble in acetone, 100% ethanol or DMSO; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol.
821, 21 (2017),
Abstract;
Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway: V. Probin, et al.; Free Radic. Biol. Med.
42, 1858 (2007),
Abstract;
Kinetic of genotoxic expression in the pharmacodynamics of busulfan: P. Morales-Ramirez, et al.; Arch. Med. Res.
37, 316 (2006),
Abstract;
DNA intrastrand cross-link at the 5’-GA-3’ sequence formed by busulfan and its role in the cytotoxic effect: T. Iwamoto, et al.; Cancer Sci.
95, 454 (2004),
Abstract;
