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Busulfan

DNA alkylating agent
 
ALX-400-048-G010 10 g 46.00 USD
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Antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5’-GA-3’ and, to a lesser extent, at 5’-GG-3’ sequences. Forms an intrastrand cross-link at the 5’-GA-3’ sequence, in addition to monoalkylation. Selectively induces normal human fibroblast senescence through Erk and p38 pathways.

Product Specification

Alternative Name:1,4-Butanediol dimethanesulfonate
 
Formula:C6H14O6S2
 
MW:246.3
 
Source:Synthetic.
 
CAS:55-98-1
 
MI:14: 1505
 
RTECS:EK1750000
 
Purity:≥98% (Assay)
 
Identity:Determined by NRM and LCMS.
 
Appearance:White to off-white crystalline powder.
 
Solubility:Soluble in acetone, 100% ethanol or DMSO; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
400-048
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400-048

Product Literature References

Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway: V. Probin, et al.; Free Radic. Biol. Med. 42, 1858 (2007), Abstract;
Kinetic of genotoxic expression in the pharmacodynamics of busulfan: P. Morales-Ramirez, et al.; Arch. Med. Res. 37, 316 (2006), Abstract;
DNA intrastrand cross-link at the 5’-GA-3’ sequence formed by busulfan and its role in the cytotoxic effect: T. Iwamoto, et al.; Cancer Sci. 95, 454 (2004), Abstract;

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