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Doxycycline . hyclate

MMP inhibitor
 
ALX-380-273-G001 1 g 35.00 USD
 
ALX-380-273-G005 5 g 74.00 USD
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Broad spectrum antibiotic and bacteriostatic. Shows antiprotozoal properties. Potent inhibitor of MMPs (matrix metalloproteinases) in vivo. Inhibits collagen synthesis. Increases and promotes smooth muscle cell adhesion. Inhibits proliferation and migration. Protects microvasculature by inhibiting plasminogen systems.

Product Specification

Alternative Name:Doxycycline . hydrochloride . hemiethanolate . hemihydrate
 
Formula:C46H58Cl2N4O18
 
MW:1025.87 g/mol
 
Source:Semisynthetic from oxytetracycline.
 
CAS:24390-14-5
 
MI:14: 3440
 
RTECS:QI8925000
 
Purity:≥98% (HPLC)
 
Identity:Determined by IR.
 
Appearance:Yellow crystalline solid.
 
Activity:Potency is 800-920 µg/mg (on dry basis).
 
Solubility:Soluble in water (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Hygroscopic.
 
ALX-380-273 structure
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ALX-380-273 structure

Product Literature References

Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia: D. Burggraf, et al.; Neurobiol. Dis. 25, 506 (2007), Abstract;
Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices: C. Franco, et al.; Am. J. Pathol. 168, 1697 (2006), Abstract; Full Text
Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry: R.A. Garcia, et al.; Mol. Pharmacol. 67, 1128 (2005), Abstract; Full Text
Doxycycline and tissue repair in rats: S. Lamparter, et al.; J. Lab. Clin. Med. 139, 295 (2002), Abstract;
Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline: R. Hanemaaijer, et al.; J. Biol. Chem. 272, 31504 (1997), Abstract; Full Text
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential: K. Suomalainen, et al.; Antimicrob. Agents Chemother. 36, 227 (1992), Abstract;
An efficacy trial of doxycycline chemoprophylaxis against leptospirosis: E.T. Takafuji, et al.; N. Engl. J. Med. 310, 497 (1984), Abstract;
A compilation of LD50 values in newborn and adult animals: E.I. Goldenthal; Toxicol. Appl. Pharmacol. 18, 185 (1971), Abstract;
Alpha-6-deoxyoxytetracycline. I. Some biological properties: A.R. English; Proc. Soc. Exp. Biol. Med. 122, 1107 (1966), Abstract;

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