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Bafilomycin B1

V-ATPase inhibitor
 
ALX-380-063-M001 1 mg 246.00 USD
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Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase.

Product Specification

Formula:C44H65NO13
 
MW:816.0
 
Source:Isolated from Streptomyces griseus.
 
CAS:88899-56-3; 80112-34-1
 
Purity:≥95% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:Yellow solid.
 
Solubility:Slightly soluble in methanol or DMSO; insoluble in water.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Handling:Protect from light when in solution.
 
380-063
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380-063

Product Literature References

Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006), Abstract;
Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A: T. Schuhmann and S. Grond; J. Antibiot. (Tokyo) 57, 655 (2004), Abstract;
Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Drose and K. Altendorf; J. Exp. Biol. 200, 1 (1997), Abstract;
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984), Abstract;

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