Arcyriaflavin A

CDK4/cyclin D1 inhibitor



ALX-350-375-M001	1 mg	165.00 USD

Potent inhibitor of CDK4 / cyclin D1 (IC₅₀= 59nM). Inhibits human cytomegalovirus (HCMV) replication in cell culture (IC₅₀ = 200nM).

Product Specification

Formula:	C₂₀H₁₁N₃O₂

MW:	325.3

Purity:	≥95% (HPLC)

Appearance:	Orange to red solid.

CAS:	118458-54-1

Source/Host:	Synthetic. Originally isolated from the marine ascidian Eudistoma sp.

Solubility:	Soluble in DMSO (50mg/ml).

Long Term Storage:	-20°C

Use/Stability:	Stock solutions are stable for up to 3 months at -20°C.

Handling:	After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Protect from light.

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Product Literature References

Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2: R. Liu, et al.; Arch. Pharm. Res. 30, 270 (2007), Abstract;

Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors: C. Sanchez-Martinez, et al.; Bioorg. Med. Chem. Lett. 13, 3835 (2003), Abstract;

Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors: G. Zhu, et al.; Bioorg. Med. Chem. Lett. 13, 1231 (2003), Abstract;

Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication: M.J. Slater, et al.; Bioorg. Med. Chem. 7, 1067 (1999), Abstract;

Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp: P.A. Horton, et al.; Experientia 50, 843 (1994), Abstract;