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Rotenone

 
ALX-350-360-G001 1 g 62.00 USD
 
ALX-350-360-G005 5 g 182.00 USD
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Replaces Prod. #: BML-CM117

Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC50=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding. Can inhibit mitochondrial swelling and cytochrome c release induced by N-methyl-4-phenylpyridinium.

Product Specification

Formula:C23H22O6
 
MW:394.4
 
Source:Isolated from Lonchocarpus sp. or Derris sp.
 
CAS:83-79-4
 
MI:14: 8271
 
RTECS:DJ2800000
 
Purity:≥98% (UHPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO or 100% ethanol; slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
350-360
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350-360

Product Literature References

Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson’s Disease: M. Marella, et al.; PLoS ONE 3, e1433 (2008), Abstract; Full Text
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells: J. Jin, et al.; BMC Neurosci. 8, 67 (2007), Abstract; Full Text
Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding: P. Srivastava & D. Panda; FEBS J. 274, 4788 (2007), Abstract;
Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons: Q. Jiang, et al.; J. Biol. Chem. 281, 29391 (2006), Abstract;
Fatality after deliberate ingestion of the pesticide rotenone: a case report: D.M. Wood, et al.; Crit Care 9, R280 (2005), Abstract; Full Text
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures: C.M. Testa, et al.; Brain Res. Mol. Brain Res. 134, 109 (2005), Abstract; Full Text
The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism: D.S. Cassarino, et al.; Biochim. Biophys. Acta 1453, 49 (1999), Abstract;
Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis: M. Higuchi, et al.; Oncogene 17, 2515 (1998), Abstract;
[3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study: D.S. Higgins, Jr. & J.T. Greenamyre; J. Neurosci. 16, 3807 (1996), Abstract; Full Text
Metabolism of rotenone in vitro by tissue homogenates from mammals and insects: J.I. Fukami, et al.; Science 155, 713 (1967), Abstract;

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