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Nodularin (linear)

Precursor of the highly toxic cyclic pentapeptide, nodularin.
 
ALX-350-182-C100 100 µg 214.00 USD
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Linear nodularin has been demonstrated to be a biosynthetic precursor of the highly toxic cyclic pentapeptide, nodularin. It is an intermediate of biodegradation by natural populations of bacteria in aquatic samples.

Product Specification

Formula:C41H62N8O11
 
MW:843.0
 
Source:Isolated from Nodularia spumigena.
 
RTECS:GU2294250
 
Purity:≥95% (HPLC)
 
Identity:Identity determined by MS.
 
Appearance:Pale powder or an oil (film), depending on the lot.
 
Solubility:Soluble in methanol:water (1:1).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:Not toxic to mice at 2 mg/kg I.P.
 
350-182 01
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Product Literature References

Biodegradation of microcystins and nodularin in freshwaters: C. Edwards, et al.; Chemosphere 73, 1315 (2008), Abstract;
Characterization of nodularin variants in Nodularia spumigena from the Baltic Sea using liquid chromatography/mass spectrometry/mass spectrometry: H. Mazur-Marzec, et al.; Rapid Commun. Mass Spectrom. 20, 2023 (2006), Abstract;
Nodularin-induced genotoxicity following oxidative DNA damage and aneuploidy in HepG2 cells: A. Lankoff, et al.; Toxicol. Lett. 164, 239 (2006), Abstract;
Bacterial degradation of microcystins and nodularin: S. Imanishi, et al.; Chem. Res. Toxicol. 18, 591 (2005), Abstract;
New Nodularins: A General Method for Structure Assignment: M. Namikoshi, et al.; J. Org. Chem. 59, 2349 (1994), Full Text
Structure and Biosynthesis of toxins from blue-green algae: K.L. Rinehart, et al.; J. Appl. Phycol. 6, 159 (1994),
Isolation of linear peptides related to the hepatotoxins nodularin and microcystins: B.W. Choi, et al; Tetrahed. Lett. 34, 7881 (1993),

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