Replaces Prod. #: BML-CM109
A steroidal inhibitor of cardiac sodium pumps (Na+/K+ ATPase) which has been recognized as an endogenous adrenal hormone. In the CNS it can be used as a tool to induce in vivo excitotoxicity. Ouabain, as well as other endogenous digitalis-like compounds, can down-regulate the expression of 14-3-3 proteins in rat lens.
Product Details
Alternative Name: | Strophanthin G, 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α-14,19-penta-hydroxycard-20(22)-enolide |
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Formula: | C29H44O12 . 8H2O |
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MW: | 584.6 . 144.2 |
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CAS: | 11018-89-6 |
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MI: | 14: 6901 |
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Purity: | ≥98% (TLC) |
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Appearance: | White solid. |
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Solubility: | Soluble in water (>25mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | +4°C |
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Handling: | Protect from light. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Application(s): Cell Culture,
Abstract;
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Abstract;
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Na+,K+-ATPase and hormone ouabain:new roles for an old enzyme and an old inhibitor: R.G. Contreras, et al.; Cell. Mol. Biol.
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Abstract;
Vascular endothelium as a target for endogenous ouabain: studies on the effect of ouabain on human endothelial cells: L. Trevisi, et al.; Cell. Mol. Biol.
52, 64 (2006), (Review),
Abstract;
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem.
280, 832 (2005),
Abstract;
Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases: W.B. Veldhuis, et al.; J. Neurosci.
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Abstract;
Endogenous cardiac glycosides, a new class of steroid hormones: W. Schoner; Eur. J. Biochem.
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Abstract;
The cardiac sodium pump: structure and function: A.A. McDonnough, et al.; Basic Res. Cardiol.
97 Suppl1, I19 (2002),
Abstract;
Digitalis and digitalislike compounds down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens: D. Lichtstein, et al.; Hypertens. Res.
23 Suppl., S51 (2000),
Abstract;
Allosteric regulation of the access channels to the Rb+ occlusion sites of (Na+ + K+)-ATPase: J. Hasenauer, et al.; J. Biol. Chem.
268, 3289 (1993),
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Charge movement by the Na/K pump in Xenopus oocytes: R.F. Rakowski; J. Gen. Physiol.
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Abstract;
Resting membrane potential and potassium currents in cultured parasympathetic neurones from rat intracardiac ganglia: Z.J. Xu & D.J. Adams; J. Physiol.
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Abstract;
Subchronic methamphetamine treatment enhances ouabain-induced striatal dopamine efflux in vivo: A. Kanzaki, et al.; Brain Res.
569, 181 (1992),
Abstract;
Actions of bufalin and cinobufotalin, two bufadienolides respectively more active and less active than ouabain, on ouabain binding and 86Rb uptake by human erythrocytes: A.A. Brownlee, et al.; Clin. Sci. (Lond.)
78, 169 (1990),
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Subacute noradrenergic agonist infusions in vivo increase Na+, K+- ATPase and ouabain binding in rat cerebral cortex: A.C. Swann & J.D. Steketee; J. Neurochem.
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Abstract;