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D-myo-Inositol 1,4,5-trisphosphate . hexapotassium salt



ALX-307-007-M001	1 mg	155.00 USD

ALX-307-007-M005	5 mg	695.00 USD
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Replaces Prod. #: BML-CA430

Product of phosphatidylinositol phospholipid hydrolysis. Causes release of calcium from intracellular stores.

Product Details

Alternative Name:	Ins(1,4,5)P₃ . 6K, IP3

Formula:	C₆H₉O₁₅P₃ . 6K

MW:	414.1 . 234.6

CAS:	103476-24-0

Purity:	≥98% (TLC)

Appearance:	White to off-white powder.

Solubility:	Soluble in water.

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Handling:	Protect from light and moisture. Hygroscopic.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis: M.P. Marciel, et al.; Oncotarget 9, 13407 (2018), Abstract; Full Text

Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand: Z. Ding, et al.; Mol. Pharmacol. 77, 995 (2010), Abstract;

Synthetic partial agonists reveal key steps in IP3 receptor activation: A.M. Rossi, et al.; Nat. Chem. Biol. 5, 631 (2009), Abstract; Full Text

Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111G-AT(1) receptor: M. Auger-Messier, et al.; Mol. Endocrinol. 18, 2967 (2004), Abstract; Full Text

Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase: B. Gonzalez, et al.; Mol. Cell 15, 689 (2004), Abstract; Full Text

Inositol 1,4,5-trisphosphate-activated calcium channels: C.D. Ferris & S.H. Snyder; Annu. Rev. Physiol. 54, 469 (1992), Abstract;

Inositol trisphosphate and diacylglycerol: two interacting second messengers: M.J. Berridge, et al.; Annu. Rev. Biochem. 56, 159 (1987), Abstract;

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver: S.K. Joseph, et al.; J. Biol. Chem. 259, 3077 (1984), Abstract;