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3-(4-Pyridyl)-1H-indole

ROCK inhibitor
 
ALX-270-429-M005 5 mg 35.00 USD
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A cell permeable, selective, and ATP-competitive inhibitor of Rho kinase (ROCK) activity (IC50=25µM). Does not inhibit the activation of Rho nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be less potent than Y-27632 (Prod. No. ALX-270-333).

Product Specification

Formula:C13H10N2
 
MW:194.2
 
CAS:7272-84-6
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Off-white to beige solid.
 
Solubility:Soluble in DMSO or dimethyl formamide.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 6 months when stored at -20°C.
 
Handling:Protect from light.
 
270-429
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270-429

Product Literature References

Scratch n’ screen for inhibitors of cell migration: J. Soderholm & R. Heald; Chem. Biol. 12, 263 (2005), Abstract;
Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor: J.C. Yarrow, et al.; Chem. Biol. 12, 385 (2005), Abstract;

Related Products

Y-27632 . dihydrochloride 

ROCK inhibitor
129830-38-2, ≥98% (HPLC (UV)) | Print as PDF
 
ALX-270-333-M001 1 mg 85.00 USD
 
ALX-270-333-M005 5 mg 174.00 USD
 
ALX-270-333-M025 25 mg 543.00 USD
Do you need bulk/larger quantities?
 

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