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Sodium butyrate

HDAC inhibitor. Apoptosis inducer.
 
ALX-270-301-G001 1 g 145.00 USD
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Short-chain fatty acid shown to be an inhibitor of histone deacetylases (HDACs). Induces apoptosis. Restores contextual memory in transgenic mouse model of Alzheimer's. Induces pancreatic progenitor formation. Directs differentiation of mouse embryonic stem cells to hepatocytes with Cytokine Activin A. Sodium butyrate interferes with signal transduction processes, as well as, inhibits c-myc splicing.

Product Specification

Formula:C4H7O2Na
 
MW:110.1
 
CAS:156-54-7
 
RTECS:ET6400000
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (100mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Hygroscopic.
 
270-301
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270-301

Product Literature References

Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells: K. Huber, et al.; J. Biol. Chem. 286, 22211 (2011), Abstract; Full Text
Effects of retinoic acid and sodium butyrate on gene expression, histone acetylation and inhibition of proliferation of melanoma cells: K. Demary, et al.; Cancer Lett. 163, 103 (2001), Abstract;
Reduction of telomerase activity in human liver cancer cells by a histone deacetylase inhibitor: M. Nakamura, et al.; J. Cell Physiol. 187, 392 (2001), Abstract;
Sodium Butyrate Induces Transcription from the Galpha i2 Gene Promoter through Multiple Sp1 Sites in the Promoter and by Activating the MEK- ERK Signal Transduction Pathway: J. Yang, et al.; J. Biol. Chem. 276, 25742 (2001), Abstract; Full Text
Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts: D. Bernhard, et al.; FASEB J. 13, 1991 (1999), Abstract;
Induction of the differentiated phenotype in human colon cancer cell is associated with the attenuation of subcellular tyrosine phosphorylation: B. Schwartz, et al.; Oncol. Res. 7, 277 (1995), Abstract;
Sodium butyrate inhibits histone deacetylation in cultured cells: E.P. Candido, et al.; Cell 14, 105 (1978), Abstract;

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