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5-AIQ . hydrochloride

PARP-1 inhibitor
 
ALX-270-285-M001 1 mg 56.00 USD
 
ALX-270-285-M005 5 mg 218.00 USD
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Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).

Product Specification

Alternative Name:5-Aminoisoquinolinone . HCl
 
Formula:C9H8N2O . HCl
 
MW:160.2 . 36.5
 
CAS:93117-07-8
 
Purity:≥97% (HPLC)
 
Appearance:Beige to brown powder.
 
Solubility:Soluble in water (warm).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from moisture.
 
270-285
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270-285

Product Literature References

PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier: J. Neuroinflammation; S. Rom, et al. 13, 254 (2016), Application(s): Cell culture with primary human monocytes from HIV-1/hepatitis B seronegative donors , Abstract; Full Text
Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis: B.D. Poole, et al.; Int. J. Med. Sci. 8, 88 (2011), Abstract; Full Text
Oocyte numbers in the mouse increase after treatment with 5-aminoisoquinolinone: a potent inhibitor of poly(ADP-ribosyl)ation: H. Qian, et al.; Biol. Reprod. 82, 1000 (2010), Abstract; Full Text
Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation: N.R. Jog, et al.; J. Immunol. 182, 7297 (2009), Abstract; Full Text
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008), Abstract;
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury: S. Cuzzocrea, et al.; Biochem. Pharmacol. 63, 293 (2002), Abstract;
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol. 130, 843 (2000), Abstract;

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The PARP Family & ADP Ribosylation
The PARP Family & ADP Ribosylation
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