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Rosmarinic acid

 
ALX-270-253-M010 10 mg 33.00 USD
 
ALX-270-253-M050 50 mg 94.00 USD
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Replaces Prod. #: BML-EI291

Naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties.Inhibits several complement-dependent inflammatory processes via inhibition of the C5 convertase. Anticarcinogenic. Inhibitor of lipid peroxidation, TCR-induced T cell activation and proliferation.

Product Specification

Alternative Name:(R)-α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy-benzenepropanoic acid
 
Formula:C18H16O8
 
MW:360.3
 
Source:Isolated from Rosmarinus officinalis.
 
CAS:537-15-5, 20283-92-5
 
Purity:≥97% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
ALX-270-253
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ALX-270-253

Product Literature References

Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro: S.S. Huang & R.L. Zheng; Cancer Lett. 239, 271 (2006), Abstract;
Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2): C. Renzulli, et al.; J. Appl. Toxicol. 24, 289 (2004), Abstract;
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model: N. Osakabe, et al.; Carcinogenesis 25, 549 (2004), Abstract;
Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity: M.A. Kang, et al.; Blood 101, 3534 (2003), Abstract;
Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner: J. Won, et al.; Eur. J. Immunol. 33, 870 (2003), Abstract;
Metabolism of rosmarinic acid in rats: T. Nakazawa & K. Ohsawa; J. Nat. Prod. 61, 993 (1998), Abstract;
Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes: G.T. Liu, et al.; Biochem. Pharmacol. 43, 147 (1992), Abstract;
The inhibitory effect of rosmarinic acid on complement involves the C5 convertase: P.W. Peake et al.; Int. J. Immunopharmacol. 13, 853 (1991), Abstract;
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987), Abstract;
Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid: M. Rampart, et al.; Biochem. Pharmacol. 35, 1397 (1986), Abstract;
Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid: H. Bult, et al.; Br. J. Pharmacol. 84, 317 (1985), Abstract;

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