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Tyrphostin AG 1024

IGF-1 inhibitor
 
ALX-270-217-M001 1 mg 80.00 USD
 
ALX-270-217-M005 5 mg 292.00 USD
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Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

Product Specification

Formula:C14H13BrN2O
 
MW:305.2
 
CAS:65678-07-1
 
Purity:≥98% (HPLC (UV))
 
Appearance:Yellow powder.
 
Solubility:Soluble in acetonitrile (5mg/ml), DMSO (8mg/ml), dichloromethane (23mg/ml) or methanol (5mg/ml); insoluble in 100% ethanol.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:In a dissolved form it should be stable for at least 1 month.
 
Handling:Protect from light.
 
ALX-270-217
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ALX-270-217

Product Literature References

Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells: A. Camirand & M. Pollak; Br. J. Cancer 90, 1825 (2004), Abstract;
Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins: M. Parrizas, et al.; Endocrinology 138, 1427 (1997), Abstract; Full Text
The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor: M. Ohmichi, et al.; Biochemistry 32, 4650 (1993), Abstract;

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