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Z-LEVD-FMK (Ready-to-Use)

Inhibitor of caspase-4 and -5
 
ALX-260-142-R100 100 µl 2mM 185.00 USD
 
ALX-260-142-R020 20 µl 10mM 185.00 USD
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Irreversible, cell permeable inhibitor of caspase-4. Inhibits also caspase-5.

Product Specification

Alternative Name:Caspase-4 inhibitor (fluoromethylketone)
 
Sequence:Z-Leu-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
 
MW:652.0
 
Formulation:Liquid. In DMSO.
 
Purity:≥95% (HPLC)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 

Product Literature References

Keratin 8/18 breakdown and reorganization during apoptosis: B. Schutte, et al.; Exp. Cell Res. 297, 11 (2004), Abstract;
Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase: E.L. Meyer, et al.; J. Biol. Chem. 278, 23786 (2003), Abstract; Full Text

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Caspase
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