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Z-LEVD-FMK (Ready-to-Use)

Inhibitor of caspase-4 and -5
 
ALX-260-142-R100 100 µl 2mM 195.00 USD
 
ALX-260-142-R020 20 µl 10mM 195.00 USD
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Irreversible, cell permeable inhibitor of caspase-4. Inhibits also caspase-5.

Product Specification

Alternative Name:Caspase-4 inhibitor (fluoromethylketone)
 
Sequence:Z-Leu-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
 
MW:652.0
 
Formulation:Liquid. In DMSO.
 
Purity:≥95% (HPLC)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 

Product Literature References

Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles: G. Camilli, et al.; Eur. J. Immunol. 48, 757 (2018), Abstract; Full Text
Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome: J.M. Platnich, et al.; Cell Rep. 25, 1525 (2018), Abstract;
Keratin 8/18 breakdown and reorganization during apoptosis: B. Schutte, et al.; Exp. Cell Res. 297, 11 (2004), Abstract;
Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase: E.L. Meyer, et al.; J. Biol. Chem. 278, 23786 (2003), Abstract; Full Text

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RELATED PRODUCTS

By target:
Caspase
Caspase-4
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Caspase-5 Inhibitor
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