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Ac-AAVALLPAVLLALLAPYVAD-CHO

Caspase-1 inhibitor
 
ALX-260-047-M001 1 mg 211.00 USD
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The YVAD-CHO portion of this peptide is a highly-specific, potent (Ki=1 nM) and reversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE), whose sequence is based on the pre-interleukin-1β Asp-116 cleavage site for caspase-1. The sequence linked N-terminal to YVAD-CHO (residues 1-16) has been shown to enhance cell permeability. The efficacy of the resulting chimeric peptide, for caspase-1 inhibition, is unknown.

Product Specification

Alternative Name:Caspase-1 inhibitor (aldehyde)
 
Sequence:Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
 
Formula:C97H160N20O24
 
MW:1990.5
 
Peptide Content:78-98%
 
Purity:≥97% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO (0.25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Preincubate cultured cells 1-2 hrs. with 0.1-2.0µM of the peptide, before inducing for apoptosis. Measure indicator(s) of apoptosis at a number of time points, since the effect of the inhibitor may be a delay in the onset of apoptosis, rather than permanent inhibition. It may also be helpful to determine a minimum effective concentration for the apoptosis inducer and use that concentration, when attempting to observe the effects of this peptide.
 
Handling:Keep cool and dry. After reconstitution, prepare aliquots and store at -20°C.
 

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