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Ac-DEVD-pNA

Caspase-3 substrate
 
ALX-260-033-M001 1 mg 35.00 USD
 
ALX-260-033-M005 5 mg 84.00 USD
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Replaces Prod. #: BML-P412

Colorimetric substrate for caspase-3 (CPP32) (Km=9.7µM) and related cysteine proteases. Sequence is based on PARP (poly(ADPribose) polymerase) cleavage site Asp216 for caspase-3. Cleavage is monitored colorimetrically at 405nm.

Product Specification

Alternative Name:Caspase-3 substrate (chromogenic)
 
Sequence:Ac-Asp-Glu-Val-Asp-pNA (pNA = p-Nitroaniline)
 
Formula:C26H34N6O13
 
MW:638.6
 
Formulation:Lyophilized.
 
Purity:≥97% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO or buffer, pH 7.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Always use fresh solutions.
 
Handling:Keep cool and dry.
 
Technical Info/Product Notes:λmax of pNA is 400nm.
 

Product Literature References

Estrogen Receptor β Upregulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma: C. J. Cookman, et al.; Endocrinology 156, 2395 (2015), Application(s): Functional Studies, Abstract; Full Text
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis: R. Datta et al.; J. Biol. Chem. 272, 1965 (1997), Abstract;
Substrate specificities of caspase family proteases: R.V. Talanian, et al.; J. Biol. Chem. 272, 9677 (1997), Abstract; Full Text
Activation of the CPP32 protease in apoptosis induced by 1-beta-D- arabinofuranosylcytosine and other DNA-damaging agents: R. Datta, et al.; Blood 88, 1936 (1996), Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract;
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik et al.; Nature 371, 346 (1994), Abstract;
Interleukin-1 beta converting enzyme: N.A. Thornberry; Methods Enzymol. 244, 615 (1994), Abstract;

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