Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Clusterin (secretory form) (human), (recombinant) (His-tag)

 
ALX-201-761-0010 10 µg 142.00 USD
 
ALX-201-761-0050 50 µg 404.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2
 
Source:Secreted protein produced by transfected human cells. Human clusterin (aa 23-422) is fused at the C-terminus to a His-tag.
 
UniProt ID:P10909
 
Formulation:Lyophilized. From a 0.2 μM filtered solution of 20mM PBS, pH 7.4 and 150mM sodium chloride, pH 7.4.
 
Purity:≥95% (SEC-HPLC and reducing SDS-PAGE)
 
Endotoxin Content:< 0.1ng/µg (1 IEU/µg).
 
Reconstitution:Dissolve the lyophilized protein in 1X PBS. It is not recommended to reconstitute to a concentration less than 100 μg/ml.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Working aliquots are stable for up to 3 months when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Scientific Background:Clusterin is a secretory heterodimeric disulfied-linked glycoprotein containing 449 amino acids that is expressed in virtually all tissues, and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. In addition, clusterin is up/ down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.
 

General Literature References

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.: J.C. Lambert, et al.; Nat. Genet. 41, 1094 (2009), Abstract;

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Clusterin
By biological activity:
Clusterin Recombinant protein
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Catalogs
Heat Shock Proteins & the Cellular Stress Response Catalog
Heat Shock Proteins & the Cellular Stress Response Catalog
Download as PDF

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,