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TRAIL-R4 polyclonal antibody

 
ADI-AAP-371-E 100 µg 356.00 USD
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Product Specification

Alternative Name:TRAIL receptor 4, DcR2, Death Receptor 2, TRUNDD, CD264, TNFRSF 10D, TNFRSF 10D, TNF-related apoptosis-inducing ligand receptor 4, Tumor necrosis factor receptor superfamily member 10D
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human TRAIL-R4.
 
UniProt ID:Q9UBN6
 
GenBank ID:AF029761
 
Species reactivity:Human, Mouse, Rat
 
Applications:ICC, IHC, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (10µg/ml)
Western Blot (1:1,000-1:2,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~36kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Decoy receptors (DcRs) are signaling-deficient receptors for certain members of the TNF family of cytokines, including TRAIL/Apo2L and FasL. Functional TRAIL receptors such as DR4 and DR5 transmit apoptotic signals via their intracellular death domains. In contrast, three identified TRAIL decoy receptors (DcR1, DcR2, and osteoprotegerin/OPG) completely or partially lack the signaling death domain, and/or are secreted from cells and unable to transmit intracellular signals. Thus, expression of DcRs promotes survival by sequestration of apoptotic ligands. A fourth identified decoy receptor, DcR3, binds both FasL and the vascular endothelial cell growth inhibitor (VEGI), inhibiting Fas and DR3 death signals.
 
AAP-371 WB
Western blot analysis of DcR2 in HeLa whole cell lysate with DcR2 antibody at 1:1000 dilution.
AAP-371 ICC
Immunocytochemistry analysis of HeLa cells using DcR2 antibody at 10µg/ml.
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AAP-371 WB AAP-371 ICC

Product Literature References

Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape: C. Wiel, et al.; Oncogene 35, 1596 (2016), Application(s): Immunohistochemistry, Abstract;
Expression of tumor necrosis factor-alpha-related apoptosis-inducing ligand and its receptors in rat testis during development: M. Benahmed, et al. ; Biol. Reprod. 66, 1707 (2002), Application(s): IHC using rat samples, Abstract;

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