Parkinson’s disease (PD) is a degenerative disorder that mainly affects the motor system. Symptoms include shaking, slow movement, and difficulty walking. Diagnosis usually occurs in people over 60 but early onset PD can occur in patients with a shortened life expectancy. In advanced stages, depression and dementia are also associated with the disease. The cause of Parkinson’s is believed to be both genetic and environmental and there is no known cure. PD involves the death of vital neurons in the brain. Some of these neurons produce dopamine which is essential for movement and coordination. As PD progresses, the amount of dopamine decreases. Initial treatment is typically with L-DOPA, to increase dopamine levels, and diet and exercise may also improve symptoms. We previously reported on the modulation of NAD+ levels leading to neuroprotective effects in a model of Parkinson’s disease.
Tags: Immunity, In The News, Neuroscience
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α-Synuclein (human), (recombinant) |
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| Produced in E. coli., ≥95% (SDS-PAGE) | Print as PDF | ||||||
| ALX-201-265-C100 | 100 µg | 359.00 USD |  |
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PROTEOSTAT® Thermal shift stability assay kit |
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| Accelerated screening for protein stability as a function of pH, ionic strength, and concentration. | ||||||
| Print as PDF | ||||||
| ENZ-51027-K100 | 100 tests | 233.00 USD | |
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| ENZ-51027-K400 | 400 tests | 628.00 USD | |
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PROTEOSTAT® Protein refolding and aggregation sensing kit |
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| Identify Optimal Protein Refolding Conditions and Maximize Recovery of Functional Protein | ||||||
| Print as PDF | ||||||
| ENZ-51040-KP002 | 2x96 wells | 483.00 USD | |
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PROTEOSTAT® PDI assay kit |
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| A simple, homogenous assay for screening modulators of PDI enzymatic activity | ||||||
| Fluorescent detection | Print as PDF | ||||||
| ENZ-51024-KP050 | 50 tests | 263.00 USD | |
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| ENZ-51024-KP002 | 2x96 tests | 706.00 USD | |
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PROTEOSTAT® Aggresome detection kit |
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| Robust, quantitative detection of aggresomes relevant to the study of neurodegenerative disease, liver disease and toxicology | ||||||
| Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF | ||||||
| ENZ-51035-0025 | 25 tests | 142.00 USD | |
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| ENZ-51035-K100 | 100 tests | 409.00 USD | |
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PROTEOSTAT® Protein aggregation standards |
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| The only commercially available protein aggregation standards assay! | ||||||
| Fluorescent detection, Microplate | Print as PDF | ||||||
| ENZ-51039-KP002 | 2x96 wells | 281.00 USD | |
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PROTEOSTAT® Thioredoxin-1 assay kit |
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| Fluorescent detection | Print as PDF | ||||||
| ENZ-51033-KP002 | 2x96 wells | 716.00 USD | |
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PD-1 (human), (recombinant) |
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| Produced in HEK cells. Extracellular domain of PD-1 (aa 25-167) containing a 5’-His-tag, V5 epitope tag spacer, and a FLAG-tag., ≥90% (SDS-PAGE) | Print as PDF | ||||||
| ENZ-PRT190-0050 | 50 µg | 395.00 USD | |
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PD-L1 (human), (recombinant) |
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| Produced in HEK cells. Human PD-L1 (aa 19-239) is fused at the N-terminus to a His-tag and FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF | ||||||
| ENZ-PRT223-0100 | 100 µg | 619.00 USD | |
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MEGACD40L® Protein (soluble) (human), (recombinant) |
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| High activity, high purity CD40L protein for co-stimulatory activation of an immune response | ||||||
| Produced in CHO cells. The extracellular domain of human CD40L (CD154) (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF | ||||||
| ALX-522-110-C010 | 10 µg | 670.00 USD | |
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MEGACD40L® Protein (soluble) (mouse), (recombinant) |
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| High activity, high purity CD40L protein for co-stimulatory activation of an immune response | ||||||
| Produced in CHO cells. The extracellular domain of mouse CD40L (CD154) (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag., ≥95% (SDS-PAGE) | Print as PDF | ||||||
| ALX-522-120-C010 | 10 µg | 716.00 USD | |
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Dopamine-β-hydroxylase polyclonal antibody |
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| IHC, WB | Print as PDF | ||||||
| BML-DZ1020-0050 | 50 µl | 430.00 USD | |
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Dopamine transporter (extracellular loop) polyclonal antibody |
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| IHC, WB | Print as PDF | ||||||
| BML-SA509-0100 | 100 µl | 507.00 USD | |
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AJ-76 |
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| Dopamine receptor ligand | ||||||
| 85379-09-5, ≥98% (HPLC) | Print as PDF | ||||||
| BML-D101-0010 | 10 mg | 209.00 USD | |
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Bupropion . HCl |
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| Inhibitor of dopamine and norepinephrine transporters | ||||||
| 31677-93-7, ≥98% (HPLC) | Print as PDF | ||||||
| BML-NS111-0050 | 50 mg | 91.00 USD | |
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| BML-NS111-0250 | 250 mg | 391.00 USD | |
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