The human body is composed of trillions of cells that provide structure and perform specialized functions. The immune system usually destroys any abnormal cells that occur as uncontrolled cell division can develop into malignant or begin tumors. Metastasis is the process in which cancer cells can spread to other parts of the body, destroying surrounding tissues, and cause new tumors to develop. Metalloproteinases (MMPs) are enzymes that play a major role in cell behaviors such as cell differentiation, proliferation and migration. Overproduced MMPs have been implicated in spread of cancer cells due to their ability to degrade the extracellular matrix. Other diseases can also arise from defective MMPs such as Alzheimer's, arthritis, asthma, and multiple sclerosis.
Tags: cancer, In The News, Drug Discovery
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Matrix metalloproteinase (MMP) inhibitor profiling kit, fluorometric RED |
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| Fluorescent detection, HTS, Activity assay | Print as PDF | ||||||
| BML-AK308-0001 | 96 wells | 1,273.00 USD |  |
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MMP-9 (catalytic domain) (human), (recombinant, E. coli) |
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| Produced in E. coli. Active recombinant matrix metalloproteinase-9 (MMP-9, gelatinase B, 92 kDa type IV collagenase) cloned from human cDNA. The enzyme consists of residues Phe107-Pro449 (NM_004994), which comprises the catalytic/fibronectin domain of human MMP-9, with a C-terminal purification tag. This represents a naturally-occurring active form of MMP-9 which lacks the C-terminal hemopexin domain. Activity toward its targets, such as gelatin, casein, or peptide substrates, is unaffected., ≥95% (SDS-PAGE) | Print as PDF | ||||||
| BML-SE360-0010 | 10 µg | 506.00 USD | |
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MMP-2 (catalytic domain) (human), (recombinant) |
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| Produced in yeast. Active recombinant matrix metalloproteinase-2 (MMP-2, gelatinase A, 72kDa type IV collagenase) cloned from human cDNA. The enzyme consists of residues Tyr110-Asp452, which comprises the catalytic/fibronectin domain of human MMP-2, with a C-terminal purification tag. , ≥90% (SDS-PAGE) | Print as PDF | ||||||
| BML-SE237-0010 | 10 µg | 506.00 USD | |
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MMP-3 (catalytic domain) (human), (recombinant) |
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| Produced in E. coli. Active Matrix Metalloproteinase-3 (MMP-3, stromelysin-1, transin) catalytic domain from human cDNA. The enzyme consists of the catalytic domain of human MMP-3 (Phe100-Thr272, NM_002422) with a C-terminal purification tag., ≥95% (SDS-PAGE) | Print as PDF | ||||||
| BML-SE109-0010 | 10 µg | 506.00 USD | |
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MMP-12 (catalytic domain) (human), (recombinant) |
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| Produced in E. coli. Active Matrix Metalloproteinase-12 (MMP-12, metalloelastase, macrophage elastase; often confused with neutrophil elastase) catalytic domain from human cDNA. The enzyme consists of the catalytic domain of human MMP-12 (Phe99-Leu271, NM_002426) with a C-terminal purification tag., ≥95% (SDS-PAGE) | Print as PDF | ||||||
| BML-SE138-0010 | 10 µg | 488.00 USD | |
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MMP-8 (catalytic domain) (human), (recombinant) |
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| Produced in E. coli. Active Matrix Metalloproteinase-8 (MMP-8, neutrophil collagenase, collagenase-2) catalytic domain from human cDNA. The enzyme consists of the catalytic domain of human MMP-8 (Phe99-Gln269, NM_002424) with a C-terminal purification tag. This represents a naturally-occurring active form of MMP-8 which lacks the C-terminal hemopexin domain1. MMPs lacking this domain cannot cleave native collagens; however, activity toward other targets such as gelatin, casein, or peptide substrates is unaffected., ≥90% (SDS-PAGE) | Print as PDF | ||||||
| BML-SE255-0010 | 10 µg | 506.00 USD | |
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Matrix metalloproteinase-1 (MMP-1) fluorometric drug discovery kit, RED |
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| Fluorescent detection, HTS, Activity assay | Print as PDF | ||||||
| BML-AK301-0001 | 96 wells | 714.00 USD | |
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Matrix metalloproteinase-2 (MMP-2) fluorometric drug discovery kit, RED |
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| Fluorescent detection, HTS, Activity assay | Print as PDF | ||||||
| BML-AK302-0001 | 96 wells | 714.00 USD | |
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Matrix metalloproteinase-3 (MMP-3) fluorometric drug discovery kit, GREEN |
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| Fluorescent detection, HTS, Activity assay | Print as PDF | ||||||
| BML-AK303-0001 | 96 wells | 714.00 USD | |
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Matrix metalloproteinase-7 (MMP-7) fluorometric drug discovery kit, RED |
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| Fluorescent detection, HTS, Activity assay | Print as PDF | ||||||
| BML-AK304-0001 | 96 wells | 714.00 USD | |
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MMP-12 (CT) polyclonal antibody |
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| WB | Print as PDF | ||||||
| BML-SA467-0100 | 100 µg | 372.00 USD | |
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Actinonin |
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| Protease inhibitor | ||||||
| 13434-13-4, Synthetic., ≥98% (HPLC) | Print as PDF | ||||||
| ALX-260-128-M005 | 5 mg | 138.00 USD | |
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