Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

A Peptide Targeting Senescent Cells Can Reverse Aging

Aging is a complex process with genetic and environmental factors influencing its rate of progression. In general, aging is characterized by homeostatic imbalance, inability to respond to stress, and an increased risk of age-related diseases. When cells experience stress and damage, they can either recover or undergo cell cycle arrest, otherwise known as senescence. Although senescent cells can no longer replicate, they are still metabolically active and can secrete pro-inflammatory factors. As we get older, senescent cells accumulate and can promote age-related illnesses such as arthritis, diabetes, cancer, and heart disease. Understanding cellular senescence has been a focus of anti-aging drug research – specifically, how to target senescent cells without damaging healthy cells in order to develop treatments and potentially reverse the aging process.

Previously, mice genetically modified to destroy their own senescent cells have shown a reduced buildup of plaque and increased longevity. Researchers have now developed a FOXO4 peptide that selectively induces apoptosis in only senescent cells. The FOXO4-p53 peptide prevents FOXO4 and a protective protein, p53, from interacting, which in turn prompts senescent cells to selectively undergo apoptosis, or programmed cell death. Regular infusions of the peptide can destroy senescent cells and improve health in aged mice. Hair growth, fitness stamina and healthy kidney function were all vastly improved within 1 month of peptide treatment in fast-aging mice. No negative side effects of the peptide treatment were noted. The FOXO4 peptide is currently being tested for effects on lifespan. Research into senescent cell therapy is promising and future studies will focus on human clinical trials for developing treatments for age-related diseases.
For more information: http://www.cell.com/fulltext/S0092-8674(17)30246-5

Enzo Life Sciences is your resource for a wide variety of products for your Cellular Analysis and Apoptosis research needs. With over 2000 products for the analysis of cell death, Enzo enables detection of phenotypic hallmarks of apoptotic cell death, and the complete analysis of cross-talk between PCD pathways. We offer a Cellular senescence live cell analysis assay to quantify senescence-associated β-galactosidase activity. Our easy to use p53 (human) ELISA kit is highly sensitive and makes it easy to quantify human p53 levels in cell culture supernatants, human serum, plasma and other biological fluids.

Never miss a new TechNote!

Receive our TechNotes as soon as they are published.


 
comments powered by Disqus

follow Us!

 

Related Products

p53 (human), (recombinant) (GST-tag) 

Produced in E. coli. Full length human p53 is fused to a GST-tag. | Print as PDF
 
BML-FW9370-0050 50 µg 516.00 USD
Do you need bulk/larger quantities?
 

p53 (human), (recombinant) (His-tag) 

Produced in insect cells using a baculovirus system. Full length human p53 is fused to a His-tag. | Print as PDF
 
BML-FW8820-0020 20 µg 511.00 USD
Do you need bulk/larger quantities?
 

p53 (wild type) (human), (recombinant) 

Produced in E. coli., ≥90% (SDS-PAGE), ELISA, WB, Inhibition assay | Print as PDF
 
ADI-908-265-010 10 µg 592.00 USD
Do you need bulk/larger quantities?
 

ROS-ID® Total ROS/Superoxide detection kit 

Widely cited kit to detect total ROS and Superoxide in live cells by microscopy and flow cytometry applications
Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51010 1 Kit 320.00 USD
Do you need bulk/larger quantities?
 

ROS-ID® ROS/RNS detection kit 

Widely cited kit to measure reactive oxygen and nitrogen species in live cells by fluorescence microscopy
Fluorescence microscopy | Print as PDF
 
ENZ-51001-200 1 Kit 352.00 USD
Do you need bulk/larger quantities?
 

Cell Counting Kit-8 

Simple, fast and accurate assay to measure cell proliferation and cytotoxicity
Colorimetric detection | Print as PDF
 
ALX-850-039-0100 100 tests 100.00 USD
 
ALX-850-039-KI01 500 tests 216.00 USD
 
ALX-850-039-KI02 5x500 tests 641.00 USD
Do you need bulk/larger quantities?
 

NUCLEAR-ID® Red cell cycle kit (GFP-CERTIFIED®) 

Convenient kit for studying cell cycle progression by various applications
Flow Cytometry, Fluorescence microscopy | Print as PDF
 
ENZ-51008-100 1 Kit 434.00 USD
Do you need bulk/larger quantities?
 

ROS-ID® Hypoxia/Oxidative stress detection kit 

Widely cited kit for the simultaneous analysis of hypoxia and oxidative stress by microscopy and flow cytometry applications
Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51042-0125 125 tests 133.00 USD
 
ENZ-51042-K500 500 tests 463.00 USD
Do you need bulk/larger quantities?
 

Recommend this page