Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

IL-33, released from necrotic cells, mobilizes killer T cells to respond to viral infections.

Tissue trauma is recognized by receptor-mediated detection of certain alarmins, proteins released from dead cells. However, the contribution of alarmins to antiviral immune defense has remained poorly defined. A team headed by Professors Daniel Pinchewer (University of Geneva) and Max Löhning (Charité-University of Medicine & DRFZ Berlin) discovered that viral replication causes the death of infected cells in the spleen and lymph nodes. These necrotic cells release interleukin-33 (IL-33) which notifies CD8+ T cells (CTLs) of the infection (Bonilla (2012) Science. PMID: 22323740). IL-33 is the principal alarmin discharged from the dying cells, and is necessary for the potent CTL response to replicating viruses. IL-33 signals through the ST2 receptor on activated CTLs, to promote virus control. Mice deficient in IL-33 displayed a reduced CTL response to viral infections. The findings highlight a new mechanism whereby nonhematopoietic cells release alarmins to mobilize CTL response to infection. This could be exploited to create vaccines against infectious diseases such as HIV and hepatitis C, as well as in the treatment of cancer.

Enzo Life Sciences offers a wide range of products relating to necrosis, as well as innate and adaptive immunity. Many of these products are relevant to the investigation of IL-33 as an alarmin.

 

Related Products

IL-33 (human), ELISA kit 

ELISA, Colorimetric detection | Print as PDF
 
ADI-900-201 96 wells 565.00 USD
Do you need bulk/larger quantities?
 

IL-33 soluble (human), detection set 

ELISA, Colorimetric detection | Print as PDF
 
APO-54N-025-KI01 5x96 wells 844.00 USD
Do you need bulk/larger quantities?
 

IL-33 (human), (recombinant) 

Produced in E. coli. Untagged human IL-33 (aa 112-270)., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-522-098-C010 10 µg 233.00 USD
 
ALX-522-098-3010 3x10 µg SuperPack 558.00 USD
Do you need bulk/larger quantities?
 

IL-33 (human) (homeodomain-like helix-turn-helix), (recombinant) (His-tag) 

Produced in E. coli. The homeodomain of human IL-33 (aa 1-111) is fused at the C-terminus to a His-tag., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-201-468-C010 10 µg 487.00 USD
Do you need bulk/larger quantities?
 

IL-33 (mouse), (recombinant) 

Produced in E. coli. Untagged mouse IL-33 (aa 109-266)., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-522-101-C010 10 µg 331.00 USD
 
ALX-522-101-3010 3x10 µg SuperPack 673.00 USD
Do you need bulk/larger quantities?
 

IL-33 (rat), (recombinant) 

Produced in E. coli. Untagged rat IL-33 (aa 109-264)., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-522-125-C010 10 µg 448.00 USD
Do you need bulk/larger quantities?
 

IL-33 monoclonal antibody (Nessy-1) 

Purified from ascites., ELISA, IHC (PS), IP, WB | Print as PDF
 
ALX-804-840-C100 100 µg 427.00 USD
Do you need bulk/larger quantities?
 

IL-33 monoclonal antibody (Nessy-1) (biotin conjugate) 

Purified from ascites., ELISA, IHC (PS) | Print as PDF
 
ALX-804-840B-C100 100 µg Biotin 454.00 USD
Do you need bulk/larger quantities?
 

IL-33 monoclonal antibody (Nessy-1) (preservative free) 

Purified from ascites., ELISA, IHC (PS), IP, WB | Print as PDF
 
ALX-804-840PF-C100 100 µg Preservative Free 415.00 USD
Do you need bulk/larger quantities?
 

IL-33 polyclonal antibody (AT110) 

Purified from rabbit serum., ELISA, WB | Print as PDF
 
ALX-210-933-C100 100 µg 365.00 USD
Do you need bulk/larger quantities?
 

Recommend this page

 
Keep in touch

©2022 Enzo Life Sciences, Inc.,