Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Salvaging impaired inflammasome function in elderly mice with flu

The innate immune system depends upon encoded pattern recognition receptors, such as the NOD-like receptor (NLR) family, to mount an appropriate immune response against microbial threats. Members of the NLR family, including NLRP3/NALP3, are critical components of the inflammasome, which links danger-signals to caspase-1 activation and subsequent processing and release of the pro-inflammatory cytokines IL-1β and IL-18. Dr. Heather W. Stout-Delgado of the Lovelace Respiratory Research Institute, Albuquerque, NM and colleagues demonstrated that elderly influenza A virus-infected mice produced lower levels of IL-1β (Stout-Delgado et al (2012) J Immunol;188(6):2815-24). Dendritic cells from elderly mice exhibited decreased expression of ASC, NLRP3, and capase-1 but increased expression of pro–IL-1β, pro–IL-18, and pro–IL-33, compared with cells from young infected mice. Treatment with nigericin during infection augmented IL-1β production, increased caspase-1 activity, and decreased morbidity and mortality in the elderly mice. The study provides one possible mechanism for why the elderly are more susceptible to influenza infection and suggests new approaches to enhancing immune response, thereby reducing morbidity and mortality in this population.

Enzo Life Sciences offers a wide range of products relating to innate and adaptive immunity, including reagents and kits pertaining to the NOD-like receptor family and inflammasomes.

 

Related Products

IL-33 (human), ELISA kit 

ELISA, Colorimetric detection | Print as PDF
 
ADI-900-201 96 wells 605.00 USD
Do you need bulk/larger quantities?
 

IL-33 soluble (human), detection set 

ELISA, Colorimetric detection | Print as PDF
 
APO-54N-025-KI01 5x96 wells 903.00 USD
Do you need bulk/larger quantities?
 

Caspase-1 assay kit for drug discovery 

Colorimetric detection, Fluorescent detection, HTS, Activity assay | Print as PDF
 
BML-AK701-0001 96 wells 688.00 USD
Do you need bulk/larger quantities?
 

Caspase-1 fluorometric assay kit 

Fluorescent detection, Activity assay | Print as PDF
 
ALX-850-212-KI01 25 tests 279.00 USD
Do you need bulk/larger quantities?
 

Caspase-1 colorimetric assay kit 

Colorimetric detection, Activity assay | Print as PDF
 
ALX-850-211-KI01 25 tests 284.00 USD
Do you need bulk/larger quantities?
 

NLRP3/NALP3 (human) monoclonal antibody (Nalpy3-b) 

Purified from concentrated hybridoma tissue culture supernatant., IHC (FS), IP, WB | Print as PDF
 
ALX-804-819-C100 100 µg 400.00 USD
Do you need bulk/larger quantities?
 

Caspase-1 polyclonal antibody 

ICC, IHC, IP, WB | Print as PDF
 
ALX-210-804-C100 100 µg 423.00 USD
Do you need bulk/larger quantities?
 

Caspase-1 (mouse) monoclonal antibody (1H11) 

ELISA, Flow Cytometry, WB | Print as PDF
 
ALX-804-530-C100 100 µg 457.00 USD
Do you need bulk/larger quantities?
 

Caspase-1 (mouse) monoclonal antibody (4G8) 

ELISA, Flow Cytometry, WB | Print as PDF
 
ALX-804-531-C100 100 µg 437.00 USD
Do you need bulk/larger quantities?
 

ASC polyclonal antibody 

ICC, WB | Print as PDF
 
ADI-905-173-100 100 µg 475.00 USD
Do you need bulk/larger quantities?
 

Ac-muramyl-Ala-D-Glu-amide 

NALP3 ligand
53678-77-6, Synthetic., ≥95% (HPLC) | Print as PDF
 
ALX-151-035-M001 1 mg 77.00 USD
 
ALX-151-035-M005 5 mg 204.00 USD
Do you need bulk/larger quantities?
 

Ac-muramyl-D-Ala-D-Glu-amide 

Negative control for MDP-LD
Synthetic., ≥97% (HPLC) | Print as PDF
 
ALX-151-036-M001 1 mg 118.00 USD
 
ALX-151-036-M005 5 mg 508.00 USD
Do you need bulk/larger quantities?
 

IL-1β precursor (110-123) 

Caspase substrate
≥97% | Print as PDF
 
BML-P400-0001 1 mg 120.00 USD
Do you need bulk/larger quantities?
 

IL-1β (human), (recombinant) (cell culture grade) 

Potent immunomodulator
97599-21-8, Produced in E. coli., ≥97% (SDS-PAGE) | Print as PDF
 
ALX-520-001-C010 10 µg 476.00 USD
Do you need bulk/larger quantities?
 

IL-1β (soluble) (human), (recombinant) 

Produced in E. coli. Human IL-1β (interleukin-1β) (aa 117-270) is fused to a linker peptide (10 aa) and an N-terminal FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF
 
ALX-522-056-C010 10 µg 299.00 USD
 
ALX-522-056-3010 3x10 µg SuperPack 746.00 USD
Do you need bulk/larger quantities?
 

Caspase-1 (human), (recombinant) 

Highly active caspase essential for apoptosis.
Produced in E. coli. cDNA encodes residues identical to Asn120-His404 (C-terminus) at Genbank Accession No. M87507, except for an Asp381 to Glu change, introduced to stabilize the enzyme against autoproteolysis., ≥90% (SDS-PAGE) | Print as PDF
 
BML-SE168-5000 5000 U 538.00 USD
Do you need bulk/larger quantities?
 

Ac-AAVALLPAVLLALLAPYVAD-CHO 

Caspase-1 inhibitor
≥97% (HPLC) | Print as PDF
 
ALX-260-047-M001 1 mg 262.00 USD
Do you need bulk/larger quantities?
 

Ac-YVAD-pNA 

Caspase-1 substrate
149231-66-3, ≥97% (HPLC) | Print as PDF
 
ALX-260-026-M001 1 mg 57.00 USD
 
ALX-260-026-M005 5 mg 110.00 USD
Do you need bulk/larger quantities?
 

Z-YVAD-AFC 

Caspase-1 substrate
201608-13-1, ≥95% (HPLC).
Single spot (TLC) | Print as PDF
 
ALX-260-035-M001 1 mg 75.00 USD
 
ALX-260-035-M005 5 mg 149.00 USD
Do you need bulk/larger quantities?
 

Z-YVAD-pNA 

Caspase-1 substrate
≥97% (HPLC) | Print as PDF
 
ALX-260-049-M001 1 mg 71.00 USD
 
ALX-260-049-M005 5 mg 182.00 USD
Do you need bulk/larger quantities?
 

Nigericin . sodium salt 

Potassium ionophore
28643-80-3; 28380-24-7, Streptomyces hygroscopicus, ≥98% (HPLC, TLC) | Print as PDF
 
BML-CA421-0005 5 mg 89.00 USD
Do you need bulk/larger quantities?
 

Monosodium urate (crystals) 

NLRP3 inflammasome activator
1198-77-2 | Print as PDF
 
ALX-400-047-M002 2 mg 113.00 USD
Do you need bulk/larger quantities?
 

Mito-TEMPO 

Mitochondria-targeted antioxidant
1334850-99-5, ≥95% (TLC) | Print as PDF
 
ALX-430-150-M005 5 mg 91.00 USD
Do you need bulk/larger quantities?
 

Rotenone 

83-79-4, Isolated from Lonchocarpus sp. or Derris sp., ≥97% (UHPLC) | Print as PDF
 
ALX-350-360-G001 1 g 77.00 USD
 
ALX-350-360-G005 5 g 239.00 USD
Do you need bulk/larger quantities?
 

Recommend this page