Product Details
| Alternative Name: | Factor 1 |
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| MW: | ~330 kDa |
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| Source: | Isolated from human plasma. Plasminogen depleted. |
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| UniProt ID: | P02671 (α chain), P02675 (β chain), P02679 (γ chain) |
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| Formulation: | Liquid. In 20mM sodium citrate-HCl, pH 7.4. |
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| Purity: | ≥95% |
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| Shipping: | Dry Ice |
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| Short Term Storage: | -80°C |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Fibrinogen is a soluble glycoprotein found in the plasma, with a molecular weight of 340kDa. It comprises of three pairs of non-identical polypeptide chains (alpha, 63.5kDa, beta, 56kDa, and gamma, 47kDa chains) linked to each other by disulphide bonds. Low plasma fibrinogen concentrations are therefore associated with an increased risk of bleeding due to impaired primary and secondary hemostasis. Therefore Fibrinogen is an essential component of the blood coagulation system. Also it may play key roles in the process of atherosclerotic lesion formation, with subsequent effects on cardiovascular diseases. And increasing evidence from epidemiological studies suggests that elevated plasma fibrinogen levels are associated with an increased risk of ischaemic heart disease (IHD), stroke and other thromboembolism. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Fibrin-targeting molecular MRI in inflammatory CNS disorders: J. Lohmeier, et al.; Eur. J. Nucl. Med. Imaging
49, 3692 (2022),
Abstract;
Single-cell spatiotemporal analysis reveals cell fates and functions of transplanted mesenchymal stromal cells during bone repair: C. Yang, et al.; Stem Cell Reports
17, 2318 (2022),
Abstract;
