| ENZ-ABS670PE-0200 | 200 µg | 740.00 USD |  |
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| Alternative Name: | Heat shock protein 90 |
| Clone: | AC88 |
| Host: | Mouse |
| Isotype: | IgG1κ |
| Immunogen: | Achlya ambisexualis (water mold) Hsp90. |
| UniProt ID: | Q8LLI6 |
| Source: | Purified from hybridoma tissue culture supernatant |
| Species reactivity: | Human, Mouse, Rat Beluga, C. elegans, Chicken, Dog, E. coli, Fish, Guinea pig, Hamster, Mycobacterium leprae, Monkey, Mussel, Porcine, Rabbit, Scallop, Sheep, Water mold, Fusobacterium nucleatum |
| Applications: | Flow Cytometry |
| Recommended Dilutions/Conditions: | Flow Cytometry (1:20-1:100) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS containing 0.09% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. Protect from light. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents. |
| Regulatory Status: | RUO - Research Use Only |
HSP90 monoclonal antibody (AC88) |
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| Purified from ascites, IHC (PS), WB | Print as PDF | ||||||
| ADI-SPA-830-D | 50 µg | 243.00 USD | |
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| ADI-SPA-830-F | 200 µg | 528.00 USD | |
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| ADI-SPA-830-J | 1 mg | 2,150.00 USD | |
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HSP90 monoclonal antibody (AC88) (DyLight™ 488 conjugate) |
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| Purified from ascites, Flow Cytometry | Print as PDF | ||||||
| ADI-SPA-830-488-D | 50 µg | 269.00 USD | |
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| ADI-SPA-830-488-F | 200 µg | 600.00 USD | |
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HSP90 monoclonal antibody (AC88) (PE conjugate) |
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| Purified from ascites, Flow Cytometry | Print as PDF | ||||||
| ADI-SPA-830PE-D | 50 µg | 277.00 USD | |
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| ADI-SPA-830PE-F | 200 µg | 586.00 USD | |
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HSP90 (human), (native) |
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| Produced in HeLa cells., ≥90% (SDS-PAGE; Western blot), ELISA, WB, Antigen microarray | Print as PDF | ||||||
| ADI-SPP-770-D | 50 µg | 439.00 USD | |
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| ADI-SPP-770-F | 200 µg | 1,059.00 USD | |
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HSP90α (human), (recombinant) |
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| Produced in E. coli., ≥90% (SDS-PAGE; Western blot), WB | Print as PDF | ||||||
| ADI-SPP-776-D | 50 µg | 277.00 USD | |
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| ADI-SPP-776-F | 200 µg | 641.00 USD | |
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HSP90β (human), (recombinant) |
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| Produced in E. coli., ≥85% (SDS-PAGE; Western blot), WB | Print as PDF | ||||||
| ADI-SPP-777-D | 50 µg | 262.00 USD | |
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| ADI-SPP-777-F | 200 µg | 631.00 USD | |
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