Replaces Prod. #: ALX-550-398
Endogenous TRPV1 agonist (Ki=36nM, EC50=36nM) with weak affinity for rat CB1 receptor (Ki=1.6µM). Potent inhibitor of 5-lipoxygenase (IC50=7.5nM) and of early and late events in TCR mediated T cell activation. Inhibits NF-κB dependent transcriptional activity without affecting either degradation of the cytoplasmic NF-κB inhibitory protein, IκBα, or DNA binding activity.
Product Details
| Alternative Name: | OLDA, N-[2-(3,4-Dihydroxyphenyl)ethyl]-9Z-octadecenamide |
| |
| Formula: | C26H43NO3 |
| |
| MW: | 417.6 |
| |
| CAS: | 105955-11-1 |
| |
| Purity: | ≥98% (TLC) |
| |
| Appearance: | White solid. |
| |
| Solubility: | Soluble in DMSO (20mg/ml). |
| |
| Shipping: | Dry Ice |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day. |
| |
| Handling: | Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Direct evidence for activation and desensitization of the capsaicin receptor by N-oleoyldopamine on TRPV1-transfected cell, line in gene deleted mice and in the rat: J. Szolcsanyi, et al.; Neurosci. Lett.
361, 155 (2004),
Abstract;
Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways: R. Sancho, et al.; J. Immunol.
172, 2341 (2004),
Abstract;
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia: C.J. Chu, et al.; J. Biol. Chem.
278, 13633 (2003),
Abstract;
Inhibition of in vitro prostaglandin and leukotriene biosyntheses by cinnamoyl-beta-phenethylamine and N-acyldopamine derivatives: C.F. Tseng, et al.; Chem. Pharm. Bull.
40, 396 (1992),
Abstract;
Inhibition of arachidonate 5-lipoxygenase by phenolic compounds: S. Iwakami, et al.; Chem. Pharm. Bull.
34, 3960 (1986),
Abstract;
