A selective, reversible inhibitor of N-WASP (neural Wiskott-Aldrich syndrome protein) that selectively blocks actin filament assembly. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
Product Details
| MW: | 426.15 |
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| CAS: | 253449-04-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| MeltingPoint: | 148-150°C |
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| Solubility: | Soluble in ethanol (10 mg/ml with warming) or DMSO (25 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion: B.A. Frugtniet, et al.; BMC Cancer
17, 224 (2017),
Abstract;
Full Text
WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion: E. Garcia, et al.; Sci. Rep.
6, 23590 (2016),
Application(s): Cell culture,
Abstract;
Full Text
