Replaces Prod. #: ALX-370-006
Inactive analog of U-73122 (Prod. No. BML-ST391) which only slightly inhibits phospholipase C. May be used as a negative control.
Product Details
| Alternative Name: | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-pyrrolidine-2,5-dione |
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| Formula: | C29H42N2O3 |
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| MW: | 466.7 |
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| CAS: | 142878-12-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in methylene chloride or chloroform; slightly soluble in DMSO (2mg/ml) or 100% ethanol (1mg/ml); sparingly soluble in aqueous solutions. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Effect of selective serotonin (5-HT)2B receptor agonist BW723C86 on epidermal growth factor/transforming growth factor-α receptor tyrosine kinase and ribosomal p70 S6 kinase activities in primary cultures of adult rat hepatocytes: K. Naito, et al.; Biol. Pharm. Bull.
42, 631 (2019),
Application(s): used w. adult rat liver hepatocytes,
Abstract;
Full Text
Comparative Effects of the Endogenous Agonist Glucagon-Like Peptide-1 (GLP-1)-(7-36) Amide and the Small-Molecule Ago-Allosteric Agent "Compound 2" at the GLP-1 Receptor: K. Coopman, et al.; J. Pharmacol. Exp. Ther.
334, 795 (2010),
Application(s): IP of human embryonic kidney cells,
Abstract;
Full Text
U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells: A. Tatrai, et al.; Biochim. Biophys. Acta
1224, 575 (1994),
Abstract;
A new, nongenomic estrogen action: the rapid release of intracellular calcium: P Morley, et al.; Endocrinology
131, 1305 (1992),
Abstract;
Gonadotropin-releasing hormone-stimulated intracellular Ca2+ fluctuations and luteinizing hormone release can be uncoupled from inositol phosphate production: B.E. Hawes, et al.; Endocrinology
130, 3475 (1992),
Abstract;
Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness: R.J. Smith, et al.; J. Pharmacol. Exp. Ther.
253, 688 (1990),
Abstract;
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