Myriocin

Palmitoyltransferase inhibitor



BML-SL226-0005	5 mg	109.00 USD
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Replaces Prod. #: ALX-350-274

Potent immunosuppressant ~10 to 100-fold more potent than cyclosporin A (Prod. No. BML-A195). Blocks sphingolipid biosynthesis by inhibiting serine palmitoyltransferase (K_i=0.28nM), therefore useful as a tool to deplete cells of sphingolipids. Induces apoptosis by depletion of cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC₅₀=15nM).

Product Details

Alternative Name:	ISP-1, Thermozymocidin, 2S,3R,4R,6E-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxo-6-eicosenoic acid

Formula:	C₂₁H₃₉NO₆

MW:	401.5

CAS:	35891-70-4

RTECS:	JX3890000

Purity:	≥98% (TLC)

Appearance:	White to off-white solid.

Solubility:	Soluble in DMSO (25mg/ml; heat briefly in boiling water bath) or in dilute base (5mg/ml; 50mM NaOH).

Shipping:	Blue Ice

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment: C. Hu, et al.; Microbial Spectr. 10, e0012722 (2022), Abstract;

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy: P.P. Laurila, et al.; Sci. Adv. 8, eabh4423 (2022), Abstract;

ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner: Y. Zhao; J. Lipid Res. 56, 644 (2015), Application(s): Cell Culture, Abstract; Full Text

Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model: T. Umehara, et al.; BBRC 346, 67 (2006), Abstract;

Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice: M.R. Hojjati, et al.; J. Biol. Chem. 280, 10284 (2005), Abstract;

Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast: Y. Sun, et al.; Mol. Cell. Biol. 20, 4411 (2000), Abstract; Full Text

Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells: S. Furuya, et al.; J. Neurochem. 71, 366 (1998), Abstract;

Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells: K. Hidari, et al.; J. Biol. Chem. 271, 14636 (1996), Abstract;

Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin: Y. Miyake, et al.; BBRC 211, 396 (1995), Abstract;

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite: T. Fujita, et al.; J. Antibiot. 47, 208 (1994), Abstract;