Replaces Prod. #: ALX-420-013
Blocks glucosylation of ceramide by inhibiting UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthetase). Inhibits the expression of cell surface glycolipid antigens and inhibits the growth of cultured rabbit skin fibroblasts. Possesses antitumor activity and inhibits Lewis lung carcinoma cell metastasis in vitro. Useful tool for studying the effects of cellular glycosphingolipid depletion. Enhances the apoptotic response to ionizing radiation by enhancing the ceramide signal.
Product Details
| Alternative Name: | D,L-threo-PDMP . hydrochloride, DL-PDMP |
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| Formula: | C23H38N2O3 . HCl |
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| MW: | 390.6 . 36.5 |
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| CAS: | 80938-69-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | 25mg/ml soluble in 100% ethanol, DMSO or water (50°C, vortex or sonicate). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for up to 1 year after receipt when stored at -20°C. Solutions are stable for up to 3 months when stored at -20°C. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids: J. Liu, et al.; Nat. Commun.
14, 465 (2023),
Abstract;
Probing Physical Properties of the Cellular Membrane in Senescent Cells by Fluorescence Imaging: J.H. Wi, et al.; J. Phys. Chem. B
125, 10182 (2021),
Abstract;
Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing: C. Rodriguez-Lafrasse, et al.; Int. J. Cancer
101, 589 (2002),
Abstract;
Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases: C.S. Rani, et al.; J. Biol. Chem.
270, 2859 (1995),
Abstract;
Full Text
Effects of a sphingolipid synthesis inhibitor on membrane transport through the secretory pathway: A.G. Rosenwald; Biochemistry
31, 3581 (1992),
Abstract;
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor: G.S. Shukla, et al.; Biochim. Biophys. Acta
1083, 101 (1991),
Abstract;
Use of PDMP for the Study of Glycosphingolipid Functions: N.S. Radin and J.-I. Inokuchi; Trends Glycosci. Glycotechnol.
3, 200 (1991),
Full Text
Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts: K.-I. Uemura, et al.; J. Biochem.
108, 525 (1990),
Abstract;
Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action: J.-I. Inokuchi, et al.; Cancer Res.
50, 6731 (1990),
Abstract;
Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells: J.-I. Inokuchi, et al.; J. Cell Physiol.
141, 573 (1989),
Abstract;
Antitumor activity via inhibition of glycosphingolipid biosynthesis: J.-I. Inokuchi, et al.; Cancer Lett.
38, 23 (1987),
Abstract;
Preparation of the active isomer of 1-phenyl-2-decanoylamino-3- morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase: J. Inokuchi & N.S. Radin; J. Lipid Res.
28, 565 (1987),
Abstract;
Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain: R.R. Vunnam & N.S. Radin; Chem. Phys. Lipids
26, 265 (1980),
Abstract;
