Replaces Prod. #: ALX-580-002
Potent inhibitor of α-mannosidase I. Blocks the biosynthesis of complex-type oligosaccharides. Does not inhibit the biosynthesis of lipid-linked oligosaccharides. Induces ER stress in human cells.
Product Details
| Formula: | C6H13NO4 . HCl |
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| MW: | 199.6 |
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| CAS: | 73465-43-7 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water, methanol (warm) and DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
1-Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721: Y. Lu et al.; Biochem. Biophys. Res. Commun.
344, 221 (2006),
Abstract;
Effect of retinyl acetate on the assembly of the fibronectin extracellular matrix and the processing of the fibronectin receptor beta subunit of confluent C3H/10T1/2 mouse embryo fibroblasts: S.S. Suzuki & L.H. Piette; J. Cell. Biochem.
51, 181 (1993),
Abstract;
The use of 1-deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells: J. Bischoff et al.; J. Biol. Chem.
261, 4766 (1986),
Abstract;
Inhibitors of oligosaccharide processing: U. Furhmann et al.; Biochim. Biophys. Acta
825, 95 (1985),
Abstract;
Secretion of high-mannose-type alpha 1-proteinase inhibitor and alpha 1-acid glycoprotein by primary cultures of rat hepatocytes in the presence of the mannosidase I inhibitor 1-deoxymannojirimycin: V. Gross et al.; Eur. J. Biochem.
150, 41 (1985),
Abstract;
