Replaces Prod. #: ALX-270-160
Plant alkaloid. Potent inhibitor of α- and β-glucosidases. Exhibits antiviral properties. Inhibits thyroglobulin secretion. Antitumor activity. Inhibits protein glycosylation. Prevents angiogenesis.
Product Details
| Formula: | C8H15NO4 |
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| MW: | 189.2 |
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| CAS: | 79831-76-8 |
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| MI: | 14: 1896 |
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| Purity: | ≥95% (TLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at 4°C. Stock solutions are stable for for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion: T. Duellman, et al.; Biochem. Biophys. Res. Commun.
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Application(s): Cell Culture,
Abstract;
Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells.: C. Durrant & S.E. Moore; Biochem. J.
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Abstract;
Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2.: S.P. Ahmed, et al.; BBRC
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Abstract;
The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth.: R. Pili, et al.; Cancer Res.
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Abstract;
Effects of the anti-inflammatory compounds castanospermine, mannose-6- phosphate and fucoidan on allograft rejection and elicited peritoneal exudates.: M.R. Bartlett, et al.; Immunol. Cell Biol.
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Abstract;
Simultaneous determination of sugar incorporation into glycosphingolipids and glycoproteins.: P. Paul, et al.; Anal. Biochem.
204, 265 (1992),
Abstract;
Castanospermine vs. its 6-O-butanoyl analog: a comparison of toxicity and antiviral activity in vitro and in vivo.: R.M. Ruprecht, et al.; J. Acquir. Immune Defic. Syndr.
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Abstract;
Effects of deoxymannojirimycin and castanospermine on the polarized secretion of thyroglobulin.: J. Franc, et al.; Endocrinology
126, 1464 (1990),
Abstract;
Inhibition of v-fms-induced tumor growth in nude mice by castanospermine.: G.K. Ostrander, et al.; Cancer Res.
48, 1091 (1988),
Abstract;
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.: R.A. Gruters, et al.; Nature
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Abstract;
The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles.: R. Repp, et al.; J. Biol. Chem.
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Abstract;
Full Text
Glycoproteins: their structure, biosynthesis and possible clinical implications.: H. Schachter; Clin. Biochem.
17, 3 (1984),
Abstract;
Studies on the mechanism of castanospermine inhibition of alpha- and beta-glucosidases.: R. Saul, et al.; Arch. Biochem. Biophys.
230, 668 (1984),
Abstract;
Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin.: Y.T. Pan, et al.; Biochemistry
22, 3975 (1983),
Abstract;
