Replaces Prod. #: ALX-340-026
Selective, orally active leukotriene D4 antagonist. Has been shown to bind to the γ-isoform of the peroxisome proliferator-activated receptor (PPARγ).
Product Details
| Alternative Name: | Tomelukast |
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| Formula: | C16H22N4O3 |
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| MW: | 318.4 |
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| CAS: | 88107-10-2 |
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| Purity: | ≥90% (HPLC) |
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| Appearance: | White solid. |
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| MeltingPoint: | 117-119°C |
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| Solubility: | Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or dimethyl formamide. Also soluble in 0.5M aqueous sodium bicarbonate. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Organic stock solutions are stable for at least six months when stored at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell
52, 167 (2020),
Application(s): Screening on Juvenile and adult zebrafish,
Abstract;
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma: B.M. Forman, et al.; Cell
83, 803 (1995),
Abstract;
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor: P. Tontonoz, et al.; Cell
79, 1147 (1994),
Abstract;
Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit: A. Sala, et al.; Br. J. Pharmacol.
110, 1206 (1993),
Abstract;
In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist: D.W. Snyder, et al.; J. Pharmacol. Exp. Ther.
243, 548 (1987),
Abstract;
LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther.
233, 148 (1985),
Abstract;
