Replaces Prod. #: ALX-380-205
RK-682 is a novel tyrosine phosphatase inhibitor isolated from Streptomyces sp. It inhibits the dual specificity VHR phosphatase (IC50=2.0µM) selectively over CD45 (IC50=54µM), Cdc25B and PTP1B (IC50~42µM). RK-682 inhibits cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea pig hippocampal CA1 neurons. Shows potent activity against HIV-1 protease.
Product Details
Formula: | C21H36O5 |
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MW: | 368.5 |
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CAS: | 154639-24-4 |
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Purity: | ≥98% (HPLC) |
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Appearance: | Pale yellow solid. |
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Solubility: | Soluble in DMSO (25mg/ml), 100% ethanol (10mg/ml), methanol or dimethyl formamide. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The potent inhibitors of protein tyrosine phosphatase 1B from the fruits of Melaleuca leucadendron: A. Saifudin, et al.; Pharmacognosy Res.
8, S38 (2016),
Application(s): Positive control,
Abstract;
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Insulin dependent apolipoprotein B degradation and phosphatidylinositide 3-kinase activation with microsomal translocation are restored in McArdle RH7777 cells following serum deprivation: J.D. Sparks, et al.; Biochem. Biophys. Res. Commun.
469, 326 (2015),
Application(s): Cell culture ,
Abstract;
Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition: T. Usui, et al.; Chem. Biol.
8, 1209 (2001),
Abstract;
RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase: T. Hamaguchi, et al.; FEBS Lett.
372, 54 (1995),
Abstract;
The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons: S. Fujii, et al.; Neurosci. Lett.
187, 130 (1995),
Abstract;
3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity: B.E. Roggo, et al.; J. Antibiot. (Tokyo)
47, 136 (1994),
Abstract;