STTHWGFTLS is ten times less potent than, thus a negative control for CTTHWGFTLC (Prod. No. BML-PI136), which is a specific inhibitor of the gelatinases MMP-2 and MMP-9. Can be used in in vitro studies, zymography and in situ zymography, in tissue culture, and in vivo.
Product Details
| Sequence: | H-Ser-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Ser-OH |
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| MW: | 1136.2 |
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| Source: | Synthetic. |
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| Formulation: | Lyophilized. |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (10mg/ml) or DMSO. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Protect from moisture. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro: O.P. Medina, et al.; Cancer Res.
61, 3978 (2001),
Abstract;
Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction: C. Fernandez-Patron, et al.; Circ. Res.
87, 670 (2000),
Abstract;
Tumor targeting with a selective gelatinase inhibitor: E. Koivunen, et al.; Nat. Biotechnol.
17, 768 (1999),
Abstract;
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