Inhibitor of TNF-α processing (IC50 is approximately 100 nM using in vitro TNF peptide cleavage assay), similar to TAPI-0, but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF-α (IC50=50-100 µM)1, APP (1-8 µM), ACE (10 µM), IL6R (5-10 µM), TNFRI (5-10 µM), TNFRII (25-50 µM), and ObRa (leptin receptor), but not CSF-1, from cells in culture.
Product Details
| Alternative Name: | IC2, N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine 2-aminoethyl amide |
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| Sequence: | N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine 2-aminoethyl amide |
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| Formula: | C26H37N5O5 |
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| MW: | 499.3 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Lyophilized solid. |
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| Solubility: | Soluble in DMSO or methanol |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Aliquot stock solutions and freeze at -20°C for up to one month. Do not store diluted solutions. |
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| Handling: | Hygroscopic. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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