Biosynthesis in endothelial cells. Induces vasodilation, inhibits platelet aggregation by receptor-mediated stimulation of adenylate cyclase. Cytoprotective. Fibrinolytic. Half-life under physiological conditions is 2 minutes.
Product Details
| Alternative Name: | PGI2 . Na |
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| Formula: | C20H31NaO5 |
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| MW: | 374.5 |
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| CAS: | 61849-14-7 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in basic buffer (unstable at neutral or acidic pH). The higher the pH the more stable the compound will be, but for in vitro or in vivo use pH ~9 is recommended. Solubility at pH 9.0 is ~10mg/ml. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Aqueous solution at pH 9 can be used directly in cell or tissue culture. The effects of PGI2 are short lived and may require continuous infusion in order to observe a response. |
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| Handling: | PGI2 hydrolyzes rapidly to 6-Keto-PGF1α upon exposure to moisture in the air. Store the solid either dessicated or under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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